Hepatic steatosis in young lean insulin resistant women with polycystic ovary syndrome

Markouo, A; Androulakis, II; Mourmouris, C; Tsikkini, A; Samara, C; Sougioultzis, S; Piaditis, G; Kaltsas, G

dc.contributor.author	Markouo, A	en
dc.contributor.author	Androulakis, II	en
dc.contributor.author	Mourmouris, C	en
dc.contributor.author	Tsikkini, A	en
dc.contributor.author	Samara, C	en
dc.contributor.author	Sougioultzis, S	en
dc.contributor.author	Piaditis, G	en
dc.contributor.author	Kaltsas, G	en
dc.date.accessioned	2014-03-01T02:00:25Z
dc.date.available	2014-03-01T02:00:25Z
dc.date.issued	2010	en
dc.identifier.issn	0015-0282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29098
dc.subject	NAFLD	en
dc.subject	insulin resistance	en
dc.subject	PCOS	en
dc.subject.classification	Obstetrics & Gynecology	en
dc.subject.classification	Reproductive Biology	en
dc.subject.other	FATTY LIVER-DISEASE	en
dc.subject.other	NONALCOHOLIC STEATOHEPATITIS	en
dc.subject.other	METABOLIC SYNDROME	en
dc.subject.other	MEDICAL PROGRESS	en
dc.subject.other	ADIPOSE-TISSUE	en
dc.subject.other	SENSITIVITY	en
dc.subject.other	PREVALENCE	en
dc.subject.other	AMINOTRANSFERASE	en
dc.subject.other	ASSOCIATION	en
dc.subject.other	POPULATION	en
dc.title	Hepatic steatosis in young lean insulin resistant women with polycystic ovary syndrome	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Objective: To investigate the presence of nonalcoholic fatty liver disease (NAFLD) in young lean women with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Design: Case control study. Setting: Women with PCOS and healthy controls in a metabolic day ward. Patient(s): Seventeen young lean women with PCOS and 17 matched. controls were studied prospectively. Intervention(s): Fasting blood and a glucose tolerance test. Ovarian and liver ultrasonography, and computed tomography (CT) of the liver (women with PCOS only). Main Outcome Measure(S): Anthropometric variables, biochemical and hormonal parameters, and several IR indices were determined. Hepatic lipid content was assessed with ultrasonography and CT of the liver. Result(s): Women with PCOS had higher androgen levels, and the IR indices, glucose and insulin area under the curve, QUICKI, MATSUDA, and HOMA, compared to controls. In addition to IR, women with PCOS had normal aminotransferase levels, and higher, although within the normal range, alkaline phosphatase levels compared with controls. Women with PCOS had no evidence of NAFLD by either ultrasonography or CT of the liver. Conclusion(s): Young lean women with PCOS and IR do not have evidence of NAFLD. Because of the presence of IR, follow-up is required to determine whether they are at risk of developing NAFLD. (Fertil Steril (R) 2010:93:1220-6. (C) 2010 by American Society for Reproductive Medicine.)	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	FERTILITY AND STERILITY	en
dc.identifier.isi	ISI:000275541000028	en
dc.identifier.volume	93	en
dc.identifier.issue	4	en
dc.identifier.spage	1220	en
dc.identifier.epage	1226	en