The Effect of Local Use of Nandrolone Decanoate on Rotator Cuff Repair in Rabbits

Papaspiliopoulos, A; Papadopoulou, E; Papalois, A; Papaparaskeva, K; Feroussis, J; Zoubos, A

dc.contributor.author	Papaspiliopoulos, A	en
dc.contributor.author	Papadopoulou, E	en
dc.contributor.author	Papalois, A	en
dc.contributor.author	Papaparaskeva, K	en
dc.contributor.author	Feroussis, J	en
dc.contributor.author	Zoubos, A	en
dc.date.accessioned	2014-03-01T02:00:45Z
dc.date.available	2014-03-01T02:00:45Z
dc.date.issued	2010	en
dc.identifier.issn	0894-1939	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29129
dc.subject	anabolic steroids	en
dc.subject	nandrolone decanoate	en
dc.subject	tendon injury	en
dc.subject	rotator cuff repair	en
dc.subject	tendon healing	en
dc.subject	drug abuse	en
dc.subject.classification	Surgery	en
dc.subject.other	ANABOLIC-ANDROGENIC STEROIDS	en
dc.subject.other	DORSI TENDON TRANSFER	en
dc.subject.other	RAT TENDON	en
dc.subject.other	SEVERE BURN	en
dc.subject.other	TEARS	en
dc.subject.other	RECONSTRUCTION	en
dc.subject.other	EPIDEMIOLOGY	en
dc.subject.other	OXANDROLONE	en
dc.subject.other	INJURIES	en
dc.subject.other	EXERCISE	en
dc.title	The Effect of Local Use of Nandrolone Decanoate on Rotator Cuff Repair in Rabbits	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2010	en
heal.abstract	Objective: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair. Methods: Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation. Results: Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids. Conclusions: The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor.	en
heal.publisher	TAYLOR & FRANCIS INC	en
heal.journalName	JOURNAL OF INVESTIGATIVE SURGERY	en
dc.identifier.isi	ISI:000282522600005	en
dc.identifier.volume	23	en
dc.identifier.issue	4	en
dc.identifier.spage	204	en
dc.identifier.epage	207	en