Differential histomechanical response of carotid artery in relation to species and region: mathematical description accounting for elastin and collagen anisotropy

Sokolis, DP; Sassani, S; Kritharis, EP; Tsangaris, S

dc.contributor.author	Sokolis, DP	en
dc.contributor.author	Sassani, S	en
dc.contributor.author	Kritharis, EP	en
dc.contributor.author	Tsangaris, S	en
dc.date.accessioned	2014-03-01T02:04:28Z
dc.date.available	2014-03-01T02:04:28Z
dc.date.issued	2011	en
dc.identifier.issn	0140-0118	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29436
dc.subject	Constitutive law	en
dc.subject	Elastin orthotropy	en
dc.subject	Inflation/extension	en
dc.subject	Structure-function relation	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Mathematical & Computational Biology	en
dc.subject.classification	Medical Informatics	en
dc.subject.other	STRAIN-ENERGY FUNCTION	en
dc.subject.other	MECHANICAL-PROPERTIES	en
dc.subject.other	THORACIC AORTA	en
dc.subject.other	WALL	en
dc.subject.other	BEHAVIOR	en
dc.subject.other	MEDIA	en
dc.subject.other	MODEL	en
dc.subject.other	MICROSTRUCTURE	en
dc.subject.other	ORGANIZATION	en
dc.subject.other	ADVENTITIA	en
dc.title	Differential histomechanical response of carotid artery in relation to species and region: mathematical description accounting for elastin and collagen anisotropy	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2011	en
heal.abstract	The selection of a mathematical descriptor for the passive arterial mechanical behavior has been long debated in the literature and customarily constrained by lack of pertinent data on the underlying microstructure. Our objective was to analyze the response of carotid artery subjected to inflation/extension with phenomenological and microstructure-based candidate strain-energy functions (SEFs), according to species (rabbit vs. pig) and region (proximal vs. distal). Histological variations among segments were examined, aiming to explicitly relate them with the differential material response. The Fung-type model could not capture the biphasic response alone. Combining a neo-Hookean with a two-fiber family term alleviated this restraint, but force data were poorly captured, while consideration of low-stress anisotropy via a quadratic term allowed improved simulation of both pressure and force data. The best fitting was achieved with the quadratic and Fung-type or four-fiber family SEF. The latter simulated more closely than the two-fiber family the high-stress response, being structurally justified for all artery types, whereas the quadratic term was justified for transitional and muscular arteries exhibiting notable elastin anisotropy. Diagonally arranged fibers were associated with pericellular medial collagen, and circumferentially and longitudinally arranged fibers with medial and adventitial collagen bundles, evidenced by the significant correlations of SEF parameters with quantitative histology.	en
heal.publisher	SPRINGER HEIDELBERG	en
heal.journalName	MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING	en
dc.identifier.isi	ISI:000292937700003	en
dc.identifier.volume	49	en
dc.identifier.issue	8	en
dc.identifier.spage	867	en
dc.identifier.epage	879	en