Biomechanical behavior and histological organization of the three-layered passive esophagus as a function of topography

Stavropoulou, EA; Dafalias, YF; Sokolis, DP

dc.contributor.author	Stavropoulou, EA	en
dc.contributor.author	Dafalias, YF	en
dc.contributor.author	Sokolis, DP	en
dc.date.accessioned	2014-03-01T02:08:07Z
dc.date.available	2014-03-01T02:08:07Z
dc.date.issued	2012	en
dc.identifier.issn	09544119	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29628
dc.subject	circumferential smooth muscle	en
dc.subject	Constitutive model	en
dc.subject	histology	en
dc.subject	longitudinal smooth muscle	en
dc.subject	mucosa-submucosa	en
dc.subject	striated muscle	en
dc.subject	uniaxial tensile-testing	en
dc.subject.other	Biomechanical behavior	en
dc.subject.other	Collagen content	en
dc.subject.other	Longitudinal arrangement	en
dc.subject.other	Material parameter	en
dc.subject.other	mucosa-submucosa	en
dc.subject.other	Muscle layers	en
dc.subject.other	Oblique arrangement	en
dc.subject.other	Orthogonal axis	en
dc.subject.other	Smooth muscles	en
dc.subject.other	Strain energy functions	en
dc.subject.other	Striated muscles	en
dc.subject.other	Tissue response	en
dc.subject.other	Transition zones	en
dc.subject.other	Tubular specimens	en
dc.subject.other	uniaxial tensile-testing	en
dc.subject.other	Uniaxial tensions	en
dc.subject.other	Zero-stress state	en
dc.subject.other	Biomechanics	en
dc.subject.other	Collagen	en
dc.subject.other	Computerized tomography	en
dc.subject.other	Constitutive models	en
dc.subject.other	Histology	en
dc.subject.other	Microscopic examination	en
dc.subject.other	Tensile testing	en
dc.subject.other	Two dimensional	en
dc.subject.other	Muscle	en
dc.subject.other	collagen	en
dc.subject.other	elastin	en
dc.subject.other	algorithm	en
dc.subject.other	animal	en
dc.subject.other	anisotropy	en
dc.subject.other	article	en
dc.subject.other	biological model	en
dc.subject.other	computer simulation	en
dc.subject.other	cytology	en
dc.subject.other	esophagus	en
dc.subject.other	male	en
dc.subject.other	mechanical stress	en
dc.subject.other	mucosa	en
dc.subject.other	physiology	en
dc.subject.other	smooth muscle	en
dc.subject.other	swine	en
dc.subject.other	tensile strength	en
dc.subject.other	Young modulus	en
dc.subject.other	Algorithms	en
dc.subject.other	Animals	en
dc.subject.other	Anisotropy	en
dc.subject.other	Collagen	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Elastic Modulus	en
dc.subject.other	Elastin	en
dc.subject.other	Esophagus	en
dc.subject.other	Male	en
dc.subject.other	Models, Biological	en
dc.subject.other	Mucous Membrane	en
dc.subject.other	Muscle, Smooth	en
dc.subject.other	Stress, Mechanical	en
dc.subject.other	Sus scrofa	en
dc.subject.other	Tensile Strength	en
dc.title	Biomechanical behavior and histological organization of the three-layered passive esophagus as a function of topography	en
heal.type	journalArticle	en
heal.identifier.primary	10.1177/0954411912444073	en
heal.identifier.secondary	http://dx.doi.org/10.1177/0954411912444073	en
heal.publicationDate	2012	en
heal.abstract	The zero-stress state of the mucosa-submucosa and two muscle esophageal layers has been delineated, but their multi-axial response has not, because muscle dissection may not leave tubular specimens intact for inflation/extension testing. The histomechanical behavior of the three-layered porcine esophagus was investigated in this study, through light microscopic examination and uniaxial tension, with two-dimensional strain measurement in pairs of orthogonally oriented specimens. The two-dimensional Fung-type strain-energy function described suitably the pseudo-elastic tissue response, affording faithful simulations to our data. Differences in the scleroprotein content and configuration were identified as a function of layer, topography, and orientation, substantiating the macromechanical differences found. In view of the failure and optimized material parameters, the mucosa-submucosa was stronger and stiffer than muscle, associating it with a higher collagen content. A notable topographical distribution was apparent, with data for the abdominal region differentiated from that for the cervical region, owing to the existence of inner muscle with a circumferential arrangement and of outer muscle with a longitudinal arrangement in the former region, and of both muscle layers with oblique arrangement in the latter region, with thoracic esophagus being a transition zone. Tissue from the mucosa-submucosa was stronger and stiffer longitudinally, relating with a preferential collagen reinforcement along that axis, but more extensible in the orthogonal axis. © IMechE 2012.	en
heal.journalName	Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine	en
dc.identifier.doi	10.1177/0954411912444073	en
dc.identifier.volume	226	en
dc.identifier.issue	6	en
dc.identifier.spage	477	en
dc.identifier.epage	490	en