Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model

Petri, A; Alexandratou, E; Kyriazi, M; Rallis, M; Roussis, V; Yova, D

dc.contributor.author	Petri, A	en
dc.contributor.author	Alexandratou, E	en
dc.contributor.author	Kyriazi, M	en
dc.contributor.author	Rallis, M	en
dc.contributor.author	Roussis, V	en
dc.contributor.author	Yova, D	en
dc.date.accessioned	2014-03-01T02:08:23Z
dc.date.available	2014-03-01T02:08:23Z
dc.date.issued	2012	en
dc.identifier.issn	15721000	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29652
dc.subject	Antioxidants	en
dc.subject	Fospeg	en
dc.subject	IPDT	en
dc.subject	Photosensitivity	en
dc.subject	Pinus halepensis	en
dc.subject.other	antioxidant	en
dc.subject.other	fospeg	en
dc.subject.other	liposome	en
dc.subject.other	photosensitizing agent	en
dc.subject.other	Pinus halepensis extract	en
dc.subject.other	plant extract	en
dc.subject.other	unclassified drug	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	bark	en
dc.subject.other	cancer therapy	en
dc.subject.other	clinical effectiveness	en
dc.subject.other	controlled study	en
dc.subject.other	digital imaging	en
dc.subject.other	erythema	en
dc.subject.other	evaluation	en
dc.subject.other	Fospeg interstitial photodynamic therapy	en
dc.subject.other	male	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	outcome assessment	en
dc.subject.other	photodynamic therapy	en
dc.subject.other	photosensitivity	en
dc.subject.other	pine	en
dc.subject.other	priority journal	en
dc.subject.other	process optimization	en
dc.subject.other	prostate cancer	en
dc.subject.other	tail	en
dc.subject.other	treatment duration	en
dc.subject.other	tumor regression	en
dc.subject.other	tumor volume	en
dc.subject.other	Animalia	en
dc.subject.other	Murinae	en
dc.subject.other	Mus	en
dc.subject.other	Pinus halepensis	en
dc.title	Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.pdpdt.2011.11.002	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.pdpdt.2011.11.002	en
heal.publicationDate	2012	en
heal.abstract	Background: The aim of the present research was to investigate the potential use of a natural compound rich in antioxidant agents, derived from . Pinus halepensis (. P. halepensis), to prevent PDT induced photosensitivity. The present research progressed in two levels. The first one evolved the optimization of Fospeg-interstitial photodynamic therapy (IPDT) in a prostate cancer animal model. In the second one, . P. halepensis bark extract, was evaluated for its potential use to prevent photosensitivity. Methods: Two sets of experiments were performed, IPDT only and IPDT in the presence of antioxidant. For both of them, Fospeg was administrated intravenously to SCID mice bearing prostate cancer, followed by IPDT after 6. h. For the IPDT. +. antioxidant experiments, . P. halepensis was injected intratumourously 1. h prior the tumour illumination. Treatment outcome was monitored twice a week by an imaging system and by measuring tumour dimensions using a caliper. Photosensitivity was assessed by monitoring erythema of the tail using the imaging system. Results: IPDT with Fospeg and 15. J total light energy is a therapeutic scheme that can eliminate tumours in the murine model of prostate cancer. Two months after complete tumour remission no tumour recurrence was observed. Also, the cosmetic outcome of the research was excellent. The major drawback of this treatment scheme was that 90% of the animals developed photosensitivity. The addition of . P. halepensis bark extract resulted in prevention of the photosensitivity, leaving PDT outcome unaffected. Conclusions: The combined use of PDT and the used antioxidant agent could broaden the implementation of photodynamic therapy, by eliminating photosensitivity. © 2011 Elsevier B.V..	en
heal.journalName	Photodiagnosis and Photodynamic Therapy	en
dc.identifier.doi	10.1016/j.pdpdt.2011.11.002	en
dc.identifier.volume	9	en
dc.identifier.issue	2	en
dc.identifier.spage	100	en
dc.identifier.epage	108	en