DIANA miRPath v.2.0: Investigating the combinatorial effect of microRNAs in pathways

Vlachos, IS; Kostoulas, N; Vergoulis, T; Georgakilas, G; Reczko, M; Maragkakis, M; Paraskevopoulou, MD; Prionidis, K; Dalamagas, T; Hatzigeorgiou, AG

dc.contributor.author	Vlachos, IS	en
dc.contributor.author	Kostoulas, N	en
dc.contributor.author	Vergoulis, T	en
dc.contributor.author	Georgakilas, G	en
dc.contributor.author	Reczko, M	en
dc.contributor.author	Maragkakis, M	en
dc.contributor.author	Paraskevopoulou, MD	en
dc.contributor.author	Prionidis, K	en
dc.contributor.author	Dalamagas, T	en
dc.contributor.author	Hatzigeorgiou, AG	en
dc.date.accessioned	2014-03-01T02:08:40Z
dc.date.available	2014-03-01T02:08:40Z
dc.date.issued	2012	en
dc.identifier.issn	03051048	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29694
dc.subject.other	microRNA	en
dc.subject.other	access to information	en
dc.subject.other	algorithm	en
dc.subject.other	article	en
dc.subject.other	client server application	en
dc.subject.other	cluster analysis	en
dc.subject.other	computer interface	en
dc.subject.other	DNA Intelligent Analysis miRPath v2.0	en
dc.subject.other	gene targeting	en
dc.subject.other	human	en
dc.subject.other	molecular dynamics	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	RNA analysis	en
dc.subject.other	single nucleotide polymorphism	en
dc.title	DIANA miRPath v.2.0: Investigating the combinatorial effect of microRNAs in pathways	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/nar/gks494	en
heal.identifier.secondary	http://dx.doi.org/10.1093/nar/gks494	en
heal.publicationDate	2012	en
heal.abstract	MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional analysis has been deemed central in many research pipelines. The new version of DIANA-miRPath web server was redesigned from the ground-up. The user of DNA Intelligent Analysis (DIANA) DIANA-miRPath v2.0 can now utilize miRNA targets predicted with high accuracy based on DIANA-microT-CDS and/or experimentally verified targets from TarBase v6; combine results with merging and meta-analysis algorithms; perform hierarchical clustering of miRNAs and pathways based on their interaction levels; as well as elaborate sophisticated visualizations, such as dendrograms or miRNA versus pathway heat maps, from an intuitive and easy to use web interface. New modules enable DIANA-miRPath server to provide information regarding pathogenic single nucleotide polymorphisms (SNPs) in miRNA target sites (SNPs module) or to annotate all the predicted and experimentally validated miRNA targets in a selected molecular pathway (Reverse Search module). DIANA-miRPath v2.0 is an efficient and yet easy to use tool that can be incorporated successfully into miRNA-related analysis pipelines. It provides for the first time a series of highly specific tools for miRNA-targeted pathway analysis via a web interface and can be accessed at http://www.microrna.gr/miRPathv2. © 2012 The Author(s).	en
heal.journalName	Nucleic Acids Research	en
dc.identifier.doi	10.1093/nar/gks494	en
dc.identifier.volume	40	en
dc.identifier.issue	W1	en
dc.identifier.spage	W498	en
dc.identifier.epage	W504	en