Hydroxyzine, cimetidine and vitamin C in reducing skin flap necrosis in ischemia-reperfusion injury in rats. A comparative study

Georgopoulos, S; Mastorakos, D; Kondi-Pafiti, A; Katsenis, K; Arkadopoulos, N; Kannas, D; Archontaki, M; Vestarchis, N; Kokkalis, G

dc.contributor.author	Georgopoulos, S	en
dc.contributor.author	Mastorakos, D	en
dc.contributor.author	Kondi-Pafiti, A	en
dc.contributor.author	Katsenis, K	en
dc.contributor.author	Arkadopoulos, N	en
dc.contributor.author	Kannas, D	en
dc.contributor.author	Archontaki, M	en
dc.contributor.author	Vestarchis, N	en
dc.contributor.author	Kokkalis, G	en
dc.date.accessioned	2014-03-01T02:09:19Z
dc.date.available	2014-03-01T02:09:19Z
dc.date.issued	2012	en
dc.identifier.issn	11070625	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29805
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-84863617494&partnerID=40&md5=a40f40b6e734112a53a3177483212edf	en
dc.subject	Cimetidine	en
dc.subject	Hydroxyzine	en
dc.subject	Injury	en
dc.subject	Ischemia	en
dc.subject	Reperfusion	en
dc.subject	Vitamin C	en
dc.subject.other	ascorbic acid	en
dc.subject.other	cimetidine	en
dc.subject.other	hydroxyzine	en
dc.subject.other	sodium chloride	en
dc.subject.other	unclassified drug	en
dc.subject.other	vianex	en
dc.subject.other	animal cell	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	article	en
dc.subject.other	cell viability	en
dc.subject.other	comparative study	en
dc.subject.other	controlled study	en
dc.subject.other	drug effect	en
dc.subject.other	epigastric skin flap	en
dc.subject.other	female	en
dc.subject.other	graft necrosis	en
dc.subject.other	histology	en
dc.subject.other	mast cell	en
dc.subject.other	neutrophil count	en
dc.subject.other	nonhuman	en
dc.subject.other	rat	en
dc.subject.other	reperfusion injury	en
dc.subject.other	skin flap	en
dc.subject.other	treatment duration	en
dc.subject.other	Animals	en
dc.subject.other	Ascorbic Acid	en
dc.subject.other	Cimetidine	en
dc.subject.other	Female	en
dc.subject.other	Graft Survival	en
dc.subject.other	Histamine H1 Antagonists	en
dc.subject.other	Histamine H2 Antagonists	en
dc.subject.other	Hydroxyzine	en
dc.subject.other	Injections, Intraperitoneal	en
dc.subject.other	Mast Cells	en
dc.subject.other	Necrosis	en
dc.subject.other	Neutrophils	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Sprague-Dawley	en
dc.subject.other	Reperfusion Injury	en
dc.subject.other	Skin	en
dc.subject.other	Surgical Flaps	en
dc.subject.other	Vitamins	en
dc.title	Hydroxyzine, cimetidine and vitamin C in reducing skin flap necrosis in ischemia-reperfusion injury in rats. A comparative study	en
heal.type	journalArticle	en
heal.publicationDate	2012	en
heal.abstract	Purpose: The purpose of the current experimental research was to investigate whether hydroxyzine can reduce the necrotic area in ischemia-reperfusion injury in epigastric rat skin flaps and to compare its role with Cimetidine and vitamin C. Methods: From a total of 77 ischemic rat skin flaps, 18 were treated with normal saline, 18 with vitamin C, 18 with Cimetidine and 18 with hydroxyzine before reperfusion. Flap necrotic area, neutrophils and mast cells were measured on the 7th day. Analysis of variance for multiple comparisons and post hoc Dunnett 's test were used for statistical analyses. Results: The sham group of animals (n=5) showed 0% flap necrosis. The saline-treated group demonstrated 75±15.3% of necrosis. The vitamin C, Cimetidine and hydroxyzine groups had 56.2 ± 24.4%, 25.8 ± 19.3%, and 33.6 ± 27.8% of flap necrosis, respectively. In addition, the number of neutrophils and mast cells were decreased in the pharmacologically treated groups compared with flaps perfused with normal saline (p<0.05). Conclusion: Our data suggest that administering hydroxyzine in rat epigastric skin flaps before reperfusion may attenuate necrosis, neutrophils and mast cell counts. The beneficial effect of Cimetidine was the same as hydroxyzine's but the use of vitamin C was less effective. © 2012 Zerbinis Medical Publications.	en
heal.journalName	Journal of B.U.ON.	en
dc.identifier.volume	17	en
dc.identifier.issue	2	en
dc.identifier.spage	377	en
dc.identifier.epage	382	en