In vitro drug release studies from organoclay/poly(dimethyl siloxane) nanocomposite matrices

Vasilakos, SP; Tarantili, PA

dc.contributor.author	Vasilakos, SP	en
dc.contributor.author	Tarantili, PA	en
dc.date.accessioned	2014-03-01T02:09:20Z
dc.date.available	2014-03-01T02:09:20Z
dc.date.issued	2012	en
dc.identifier.issn	15524973	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29818
dc.subject	composite/soft tissue	en
dc.subject	drug delivery/release	en
dc.subject	matrix	en
dc.subject	nanomaterials/nanophase	en
dc.subject	silicone(s)/PDMS	en
dc.title	In vitro drug release studies from organoclay/poly(dimethyl siloxane) nanocomposite matrices	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/jbm.b.32757	en
heal.identifier.secondary	http://dx.doi.org/10.1002/jbm.b.32757	en
heal.publicationDate	2012	en
heal.abstract	Silicone elastomers are versatile biomaterials and have been used for fabrication of drug release systems, usually incorporating lipophilic drugs. However, attempts have been made to extend the use of these biomaterials to the delivery of hydrophilic drugs. Furthermore, the need to improve mechanical properties of silicones led, among others, to the incorporation of organoclay nanoparticles and, therefore, has introduced some new parameters to be investigated regarding their effect on the release profile. In this work, the delivery of 2-methyl-5-nitroimidazole-1-ethanol (metronidazole) from nanocomposites with silicone matrix based on condensation cured elastomers with different molecular weights was investigated in various surrounding liquids. The results showed that incorporation of organic modified montmorillonite (OMMT) generally decreases the drug release rate and restricts the initial burst effect. Interestingly, OMMT concentrations of 2 phr in low MW silicone systems seem to enhance drug release and, independently of interpretation, it might indicate a route for the adjustment of diffusivity through the nanoclay concentration. Maximum drug release rates can rather be achieved with low MW PDMS than with the higher MW elastomers. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012. Copyright © 2012 Wiley Periodicals, Inc.	en
heal.journalName	Journal of Biomedical Materials Research - Part B Applied Biomaterials	en
dc.identifier.doi	10.1002/jbm.b.32757	en
dc.identifier.volume	100 B	en
dc.identifier.issue	7	en
dc.identifier.spage	1899	en
dc.identifier.epage	1910	en