Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

Bilalis, P; Efthimiadou, EK; Chatzipavlidis, A; Boukos, N; Kordas, GC

dc.contributor.author	Bilalis, P	en
dc.contributor.author	Efthimiadou, EK	en
dc.contributor.author	Chatzipavlidis, A	en
dc.contributor.author	Boukos, N	en
dc.contributor.author	Kordas, GC	en
dc.date.accessioned	2014-03-01T02:11:28Z
dc.date.available	2014-03-01T02:11:28Z
dc.date.issued	2012	en
dc.identifier.issn	09598103	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29917
dc.subject	Daunorubicin	en
dc.subject	Distillation precipitation polymerization	en
dc.subject	Magnetic nanoparticles	en
dc.subject	Microcontainers	en
dc.subject	PH sensitive	en
dc.subject	Thermosensitive	en
dc.subject.other	Daunorubicin	en
dc.subject.other	Distillation-precipitation polymerization	en
dc.subject.other	Magnetic nanoparticles	en
dc.subject.other	Microcontainers	en
dc.subject.other	pH sensitive	en
dc.subject.other	Thermo sensitive	en
dc.subject.other	Acrylic monomers	en
dc.subject.other	Catalyst activity	en
dc.subject.other	Distillation	en
dc.subject.other	Fourier transform infrared spectroscopy	en
dc.subject.other	Functional polymers	en
dc.subject.other	Magnetic properties	en
dc.subject.other	Medical applications	en
dc.subject.other	Nanoparticles	en
dc.subject.other	Polymerization	en
dc.subject.other	Scanning electron microscopy	en
dc.subject.other	Ultraviolet visible spectroscopy	en
dc.subject.other	X ray diffraction	en
dc.subject.other	Synthesis (chemical)	en
dc.title	Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/pi.4152	en
heal.identifier.secondary	http://dx.doi.org/10.1002/pi.4152	en
heal.publicationDate	2012	en
heal.abstract	Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe3O4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering. © 2012 Society of Chemical Industry.	en
heal.journalName	Polymer International	en
dc.identifier.doi	10.1002/pi.4152	en
dc.identifier.volume	61	en
dc.identifier.issue	6	en
dc.identifier.spage	888	en
dc.identifier.epage	894	en