Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model

Lalountas, M; Ballas, KD; Michalakis, A; Psarras, K; Asteriou, C; Giakoustidis, DE; Nikolaidou, C; Venizelos, I; Pavlidis, TE; Sakantamis, AK

dc.contributor.author	Lalountas, M	en
dc.contributor.author	Ballas, KD	en
dc.contributor.author	Michalakis, A	en
dc.contributor.author	Psarras, K	en
dc.contributor.author	Asteriou, C	en
dc.contributor.author	Giakoustidis, DE	en
dc.contributor.author	Nikolaidou, C	en
dc.contributor.author	Venizelos, I	en
dc.contributor.author	Pavlidis, TE	en
dc.contributor.author	Sakantamis, AK	en
dc.date.accessioned	2014-03-01T02:12:03Z
dc.date.available	2014-03-01T02:12:03Z
dc.date.issued	2012	en
dc.identifier.issn	00071323	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/29992
dc.subject.other	atorvastatin	en
dc.subject.other	biomaterial	en
dc.subject.other	carboxymethylcellulose	en
dc.subject.other	heptanoic acid derivative	en
dc.subject.other	hyaluronic acid	en
dc.subject.other	hydroxymethylglutaryl coenzyme A reductase inhibitor	en
dc.subject.other	pyrrole derivative	en
dc.subject.other	Seprafilm	en
dc.subject.other	animal	en
dc.subject.other	article	en
dc.subject.other	fibrosis	en
dc.subject.other	male	en
dc.subject.other	pathology	en
dc.subject.other	randomization	en
dc.subject.other	rat	en
dc.subject.other	tissue adhesion	en
dc.subject.other	Wistar rat	en
dc.subject.other	Animals	en
dc.subject.other	Biocompatible Materials	en
dc.subject.other	Carboxymethylcellulose Sodium	en
dc.subject.other	Fibrosis	en
dc.subject.other	Heptanoic Acids	en
dc.subject.other	Hyaluronic Acid	en
dc.subject.other	Hydroxymethylglutaryl-CoA Reductase Inhibitors	en
dc.subject.other	Male	en
dc.subject.other	Pyrroles	en
dc.subject.other	Random Allocation	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Wistar	en
dc.subject.other	Tissue Adhesions	en
dc.title	Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/bjs.7817	en
heal.identifier.secondary	http://dx.doi.org/10.1002/bjs.7817	en
heal.publicationDate	2012	en
heal.abstract	Background: Intraperitoneal adhesions are a common problem in abdominal surgery. The aim of this study was to compare the effectiveness of Statofilm, a novel antiadhesive film based on cross-linked carboxymethylcellulose and atorvastatin, with that of sodium hyaluronate-carboxymethylcellulose (Seprafilm®) in the prevention of postoperative intraperitoneal adhesions in rats. Methods: One hundred male Wistar rats underwent a laparotomy and adhesions were induced by caecal abrasion. The animals were allocated to five groups: a control group with no adhesion barrier, Seprafilm® group, placebo group with a film containing carboxymethylcellulose without atorvastatin, and low- and high-dose groups with films containing carboxymethylcellulose and atorvastatin 0·125 and 1 mg per kg bodyweight respectively. Adhesions were classified by two independent surgeons 2 weeks after surgery. Caecal biopsies were obtained for histological evaluation of fibrosis, inflammation and vascular proliferation. Results: All antiadhesive film groups (Seprafilm®, placebo, low-dose and high-dose) had statistically significant adhesion reduction compared with the control group (P < 0·001, P = 0·015, P < 0·001 and P < 0·001 respectively). The low-dose Statofilm was superior to Seprafilm® in terms of adhesion prevention (P = 0·001). Adhesions were present in three-quarters of rats in the Seprafilm® group, but only one-quarter in the low-dose Statofilm group. Conclusion: The data suggest that the newly developed adhesion barrier Statofilm has better results than Seprafilm® in preventing postoperative adhesions in rats. A low-dose atorvastatin-containing film, such as Statofilm, could be evaluated for future clinical application. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.	en
heal.journalName	British Journal of Surgery	en
dc.identifier.doi	10.1002/bjs.7817	en
dc.identifier.volume	99	en
dc.identifier.issue	3	en
dc.identifier.spage	423	en
dc.identifier.epage	429	en