TarBase 6.0: Capturing the exponential growth of miRNA targets with experimental support

Vergoulis, T; Vlachos, IS; Alexiou, P; Georgakilas, G; Maragkakis, M; Reczko, M; Gerangelos, S; Koziris, N; Theodore, D; Hatzigeorgiou, AG

dc.contributor.author	Vergoulis, T	en
dc.contributor.author	Vlachos, IS	en
dc.contributor.author	Alexiou, P	en
dc.contributor.author	Georgakilas, G	en
dc.contributor.author	Maragkakis, M	en
dc.contributor.author	Reczko, M	en
dc.contributor.author	Gerangelos, S	en
dc.contributor.author	Koziris, N	en
dc.contributor.author	Theodore, D	en
dc.contributor.author	Hatzigeorgiou, AG	en
dc.date.accessioned	2014-03-01T02:14:47Z
dc.date.available	2014-03-01T02:14:47Z
dc.date.issued	2012	en
dc.identifier.issn	03051048	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/30113
dc.subject.other	microRNA	en
dc.subject.other	access to information	en
dc.subject.other	article	en
dc.subject.other	computer interface	en
dc.subject.other	controlled study	en
dc.subject.other	DIANA	en
dc.subject.other	Ensembl	en
dc.subject.other	gene interaction	en
dc.subject.other	genetic database	en
dc.subject.other	high throughput sequencing	en
dc.subject.other	human	en
dc.subject.other	information processing	en
dc.subject.other	Internet	en
dc.subject.other	priority journal	en
dc.subject.other	protein database	en
dc.subject.other	protein function	en
dc.subject.other	protein targeting	en
dc.subject.other	RefSeq	en
dc.subject.other	RNA sequence	en
dc.subject.other	TarBase 6.0	en
dc.subject.other	UniProt	en
dc.subject.other	Data Mining	en
dc.subject.other	Databases, Nucleic Acid	en
dc.subject.other	Disease	en
dc.subject.other	Gene Silencing	en
dc.subject.other	Humans	en
dc.subject.other	MicroRNAs	en
dc.subject.other	User-Computer Interface	en
dc.title	TarBase 6.0: Capturing the exponential growth of miRNA targets with experimental support	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/nar/gkr1161	en
heal.identifier.secondary	http://dx.doi.org/10.1093/nar/gkr1161	en
heal.publicationDate	2012	en
heal.abstract	As the relevant literature and the number of experiments increase at a super linear rate, databases that curate and collect experimentally verified microRNA (miRNA) targets have gradually emerged. These databases attempt to provide efficient access to this wealth of experimental data, which is scattered in thousands of manuscripts. Aim of TarBase 6.0 (http://www.microrna.gr/ tarbase) is to face this challenge by providing a significant increase of available miRNA targets derived from all contemporary experimental techniques (gene specific and high-throughput), while incorporating a powerful set of tools in a user-friendly interface. TarBase 6.0 hosts detailed information for each miRNA-gene interaction, ranging from miRNA- and gene-related facts to information specific to their interaction, the experimental validation methodologies and their outcomes. All database entries are enriched with function-related data, as well as general information derived from external databases such as UniProt, Ensembl and RefSeq. DIANA microT miRNA target prediction scores and the relevant prediction details are available for each interaction. TarBase 6.0 hosts the largest collection of manually curated experimentally validated miRNA-gene interactions (more than 65 000 targets), presenting a 16.5-175-fold increase over other available manually curated databases. © The Author(s) 2011. Published by Oxford University Press.	en
heal.journalName	Nucleic Acids Research	en
dc.identifier.doi	10.1093/nar/gkr1161	en
dc.identifier.volume	40	en
dc.identifier.issue	D1	en
dc.identifier.spage	D222	en
dc.identifier.epage	D229	en