The interplay between inflammation and oxidative stress in carcinogenesis

Nowsheen, S; Aziz, K; Kryston, TB; Ferguson, NF; Georgakilas, A

dc.contributor.author	Nowsheen, S	en
dc.contributor.author	Aziz, K	en
dc.contributor.author	Kryston, TB	en
dc.contributor.author	Ferguson, NF	en
dc.contributor.author	Georgakilas, A	en
dc.date.accessioned	2014-03-01T02:14:49Z
dc.date.available	2014-03-01T02:14:49Z
dc.date.issued	2012	en
dc.identifier.issn	15665240	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/30134
dc.subject	Carcinogenesis	en
dc.subject	DNA damage	en
dc.subject	Genomic instability	en
dc.subject	Inflammation	en
dc.subject	Oxidative stress	en
dc.subject	Tumor microenvironment	en
dc.subject.other	alpha tocopherol	en
dc.subject.other	beta catenin	en
dc.subject.other	bevacizumab	en
dc.subject.other	BRCA1 protein	en
dc.subject.other	capecitabine	en
dc.subject.other	catalase	en
dc.subject.other	caveolin 1	en
dc.subject.other	ferritin	en
dc.subject.other	gelatinase A	en
dc.subject.other	glutathione peroxidase	en
dc.subject.other	hydroxyl radical	en
dc.subject.other	hypoxia inducible factor 1alpha	en
dc.subject.other	iron	en
dc.subject.other	macrophage migration inhibition factor	en
dc.subject.other	nicotinamide adenine dinucleotide phosphate	en
dc.subject.other	protein c fos	en
dc.subject.other	protein c jun	en
dc.subject.other	protein p53	en
dc.subject.other	Rac1 protein	en
dc.subject.other	reactive nitrogen species	en
dc.subject.other	reactive oxygen metabolite	en
dc.subject.other	redox effector factor 1	en
dc.subject.other	scatter factor	en
dc.subject.other	superoxide dismutase	en
dc.subject.other	transcription factor Snail	en
dc.subject.other	transcription factor Twist	en
dc.subject.other	transforming growth factor beta	en
dc.subject.other	uvomorulin	en
dc.subject.other	angiogenesis	en
dc.subject.other	apoptosis	en
dc.subject.other	article	en
dc.subject.other	autophagy	en
dc.subject.other	breast cancer	en
dc.subject.other	cancer chemotherapy	en
dc.subject.other	cancer prognosis	en
dc.subject.other	carcinogenesis	en
dc.subject.other	cell death	en
dc.subject.other	cell invasion	en
dc.subject.other	cell migration	en
dc.subject.other	cell proliferation	en
dc.subject.other	cell survival	en
dc.subject.other	chemoprophylaxis	en
dc.subject.other	DNA damage	en
dc.subject.other	DNA methylation	en
dc.subject.other	double stranded DNA break	en
dc.subject.other	endothelial progenitor cell	en
dc.subject.other	epithelial mesenchymal transition	en
dc.subject.other	excision repair	en
dc.subject.other	fibroblast	en
dc.subject.other	genomic instability	en
dc.subject.other	heterozygosity loss	en
dc.subject.other	homologous recombination	en
dc.subject.other	human	en
dc.subject.other	hypoxia	en
dc.subject.other	inflammation	en
dc.subject.other	metastasis	en
dc.subject.other	microsatellite instability	en
dc.subject.other	mismatch repair	en
dc.subject.other	mutagenesis	en
dc.subject.other	nonhuman	en
dc.subject.other	overall survival	en
dc.subject.other	oxidative stress	en
dc.subject.other	pH	en
dc.subject.other	phase 3 clinical trial (topic)	en
dc.subject.other	stroma	en
dc.subject.other	tissue pressure	en
dc.subject.other	tumor growth	en
dc.subject.other	tumor microenvironment	en
dc.title	The interplay between inflammation and oxidative stress in carcinogenesis	en
heal.type	journalArticle	en
heal.identifier.primary	10.2174/156652412800792642	en
heal.identifier.secondary	http://dx.doi.org/10.2174/156652412800792642	en
heal.publicationDate	2012	en
heal.abstract	Emerging data suggest that primary dysfunction in the tumor microenvironment is crucial for carcinogenesis. These recent findings make a compelling case for targeting the milieu for cancer chemoprevention as well as therapy. The stroma is an integral part of its physiology, and functionally, one cannot totally dissociate the tumor surrounding from the tumor cells. A thorough understanding of the tumor and stroma will aid us in developing new treatment targets. In this review, we shed light at the key aspects of the carcinogenic process and how oxidative stress and inflammation contribute to this process. We dissect the connection between metastasis and oxidative stress and focus on the key players in the tumor microenvironment that leads to inflammation, oxidative stress and DNA damage. Moreover, we consider the role of inflammation in disease, specifically cancer and metastasis. Finally, we discuss the potential applications in prognosis and cancer treatment. © 2012 Bentham Science Publishers.	en
heal.journalName	Current Molecular Medicine	en
dc.identifier.doi	10.2174/156652412800792642	en
dc.identifier.volume	12	en
dc.identifier.issue	6	en
dc.identifier.spage	672	en
dc.identifier.epage	680	en