Time course of flow-induced adaptation of carotid artery biomechanical properties, structure and zero-stress state in the arteriovenous shunt

Kritharis, EP; Giagini, AT; Kakisis, JD; Dimitriou, CA; Stergiopulos, N; Tsangaris, S; Sokolis, DP

dc.contributor.author	Kritharis, EP	en
dc.contributor.author	Giagini, AT	en
dc.contributor.author	Kakisis, JD	en
dc.contributor.author	Dimitriou, CA	en
dc.contributor.author	Stergiopulos, N	en
dc.contributor.author	Tsangaris, S	en
dc.contributor.author	Sokolis, DP	en
dc.date.accessioned	2014-03-01T02:14:51Z
dc.date.available	2014-03-01T02:14:51Z
dc.date.issued	2012	en
dc.identifier.issn	0006355X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/30148
dc.subject	Arteriovenous shunt	en
dc.subject	biomechanical properties	en
dc.subject	collagen	en
dc.subject	elastin	en
dc.subject	opening angle	en
dc.subject	remodeling	en
dc.subject.other	elastin	en
dc.subject.other	adventitia	en
dc.subject.other	animal experiment	en
dc.subject.other	animal tissue	en
dc.subject.other	arterial wall thickness	en
dc.subject.other	arteriovenous shunt	en
dc.subject.other	artery compliance	en
dc.subject.other	artery diameter	en
dc.subject.other	article	en
dc.subject.other	bioaccumulation	en
dc.subject.other	biomechanics	en
dc.subject.other	carotid artery	en
dc.subject.other	carotid artery flow	en
dc.subject.other	confocal microscopy	en
dc.subject.other	connective tissue	en
dc.subject.other	controlled study	en
dc.subject.other	euthanasia	en
dc.subject.other	fragmentation reaction	en
dc.subject.other	hemodynamics	en
dc.subject.other	in vitro study	en
dc.subject.other	in vivo study	en
dc.subject.other	jugular vein	en
dc.subject.other	male	en
dc.subject.other	microscopy	en
dc.subject.other	nonhuman	en
dc.subject.other	postoperative period	en
dc.subject.other	shear flow	en
dc.subject.other	shear stress	en
dc.subject.other	swine	en
dc.subject.other	tissue growth	en
dc.title	Time course of flow-induced adaptation of carotid artery biomechanical properties, structure and zero-stress state in the arteriovenous shunt	en
heal.type	journalArticle	en
heal.identifier.primary	10.3233/BIR-2012-0602	en
heal.identifier.secondary	http://dx.doi.org/10.3233/BIR-2012-0602	en
heal.publicationDate	2012	en
heal.abstract	Numerous studies have provided evidence of diameter adaptation secondary to flow-overload, but with ambiguous findings vis à vis other morphological parameters and information on the biomechanical aspects of arterial adaptation is rather incomplete. We examined the time course of large-artery biomechanical adaptation elicited by long-term flow-overload in a porcine shunt model between the carotid artery and ipsilateral jugular vein. Post-shunting, the proximal artery flow was doubled and retained so until euthanasia (up to three months post-operatively), without pressure change. This hemodynamic stimulus induced lumen diameter enlargement, accommodated by elastin fragmentation and connective tissue accumulation, as witnessed by optical and confocal microscopy. Heterogeneous mass growth of the adventitia was observed at the expense of the media, associated with declining residual strains and opening angle at three months. The in vitro elastic properties of shunted arteries determined by inflation/extension testing were also modified, with the thickness-pressure curves shifted to larger thicknesses and the diameter-pressure curves shifted to larger diameters at physiologic pressures, resulting in normalization of intramural and shear stresses within fifteen and thirty days, respectively. We infer that the biomechanical adaptation in moderate flow-overload leads to normalization of intimal shear, without, however, restoring compliance and distensibility at mean in vivo pressure to control levels. © 2012 - IOS Press and the authors. All rights reserved.	en
heal.journalName	Biorheology	en
dc.identifier.doi	10.3233/BIR-2012-0602	en
dc.identifier.volume	49	en
dc.identifier.issue	1	en
dc.identifier.spage	65	en
dc.identifier.epage	82	en