Dielectric changes precede hydrogen bond breakage during helix to coil transition of deoxyribonucleic acid

Georgakilas Alexandros, G; Haveles Kostas, S; Konsta, Amalia; Sideris Eleftherios, G

dc.contributor.author	Georgakilas Alexandros, G	en
dc.contributor.author	Haveles Kostas, S	en
dc.contributor.author	Konsta, Amalia	en
dc.contributor.author	Sideris Eleftherios, G	en
dc.date.accessioned	2014-03-01T02:41:11Z
dc.date.available	2014-03-01T02:41:11Z
dc.date.issued	1996	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/30413
dc.subject	deoxyribonucleic acid	en
dc.subject	Hydrogen Bond	en
dc.subject	Ionizing Radiation	en
dc.subject	Thermodynamic Stability	en
dc.subject	Low Dose	en
dc.subject	Molecular Weight	en
dc.subject.other	Biology	en
dc.subject.other	DNA	en
dc.subject.other	Gamma rays	en
dc.subject.other	Hydrogen bonds	en
dc.subject.other	Molecular weight	en
dc.subject.other	Molecules	en
dc.subject.other	Phase transitions	en
dc.subject.other	Radiation	en
dc.subject.other	Thermodynamic stability	en
dc.subject.other	Alpha irradiation	en
dc.subject.other	Helix to coil transition	en
dc.subject.other	Radiation biology	en
dc.subject.other	Thermal transition	en
dc.subject.other	Dielectric properties	en
dc.title	Dielectric changes precede hydrogen bond breakage during helix to coil transition of deoxyribonucleic acid	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/ISE.1996.578201	en
heal.identifier.secondary	http://dx.doi.org/10.1109/ISE.1996.578201	en
heal.publicationDate	1996	en
heal.abstract	An interesting and simultaneously unexpected thermodynamic stability of the DNA helix was observed when studying the effects of exposure to γ- and α-irradiation on the double helix to coil thermal transition phase of mammalian macromolecular DNA. The results show that at the low dose range, of 0 to 12 Gy, which is of importance for the radiation biology and where the effects of exposure to ionizing radiation were not explored in the previously published work, an increase of the dose of ionizing radiation results in an increase of the thermodynamic stability as well as in an increase of the apparent molecular weight of the DNA macromolecules. In all cases conductivity changes precede by a ΔT of about 3°C the helix to coil transition changes, as those are measured by the breakage of the intramolecular hydrogen bonds. This ΔT is independent of the effected molecular weight changes.	en
heal.publisher	IEEE, Piscataway, NJ, United States	en
heal.journalName	Proceedings - International Symposium on Electrets	en
dc.identifier.doi	10.1109/ISE.1996.578201	en
dc.identifier.spage	747	en
dc.identifier.epage	752	en