Metal-DNA interactions

Anastassopoulou, J

dc.contributor.author	Anastassopoulou, J	en
dc.date.accessioned	2014-03-01T02:42:17Z
dc.date.available	2014-03-01T02:42:17Z
dc.date.issued	2003	en
dc.identifier.issn	0022-2860	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/30912
dc.subject	DNA	en
dc.subject	FT-IR spectra	en
dc.subject	Metal ions	en
dc.subject	Metal-DNA complexes	en
dc.subject	RNA	en
dc.subject	Structures	en
dc.subject.classification	Chemistry, Physical	en
dc.subject.other	DNA	en
dc.subject.other	metal	en
dc.subject.other	oxygen	en
dc.subject.other	phosphate	en
dc.subject.other	purine	en
dc.subject.other	pyrimidine	en
dc.subject.other	RNA	en
dc.subject.other	water	en
dc.subject.other	base pairing	en
dc.subject.other	conference paper	en
dc.subject.other	DNA helix	en
dc.subject.other	DNA replication	en
dc.subject.other	DNA structure	en
dc.subject.other	DNA synthesis	en
dc.subject.other	hydrogen bond	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	metal binding	en
dc.subject.other	molecule	en
dc.subject.other	protein interaction	en
dc.subject.other	spectroscopy	en
dc.subject.other	X ray analysis	en
dc.title	Metal-DNA interactions	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1016/S0022-2860(02)00625-7	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0022-2860(02)00625-7	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Metal ions can bind to DNA directly or indirectly through hydrogen bonding of the coordinating water molecules surrounding the metal ions. Metal binding to the bases usually disrupts base pair hydrogen bonding and destabilizes the double helix. Spectroscopic and X-ray data shows that the N7 atom of the purine or N3 of pyrimidine residues as well as exocyclic O atoms and the phosphate oxygen atoms are the preferential sites of metal binding. The binding of metals to DNA and RNA also influences indirectly the sugar conformation. As a result of this change in sugar puckering the two helical conformations of A-DNA and B-DNA or RNA are characterized by the orientation of the bases with respect to the axis of the double helix. This may be the reason why some metal ions influence DNA synthesis and the replication process. In this paper we describe the influence of metal ion binding on the DNA structure and the variation of binding behaviour of different metal ions. (C) 2003 Elsevier Science B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Molecular Structure	en
dc.identifier.doi	10.1016/S0022-2860(02)00625-7	en
dc.identifier.isi	ISI:000183424200003	en
dc.identifier.volume	651-653	en
dc.identifier.spage	19	en
dc.identifier.epage	26	en