Stochastic modeling and validation of growth saturation and radiotherapeutic response of multicellular tumor spheroids

Zacharaki, EI; Stamatakos, GS; Nikita, KS; Uzunoglu, NK

dc.contributor.author	Zacharaki, EI	en
dc.contributor.author	Stamatakos, GS	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Uzunoglu, NK	en
dc.date.accessioned	2014-03-01T02:42:58Z
dc.date.available	2014-03-01T02:42:58Z
dc.date.issued	2004	en
dc.identifier.issn	05891019	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/31164
dc.subject	Fractionation	en
dc.subject	Multicellular spheroid	en
dc.subject	Radiation	en
dc.subject	Radiosensitivity	en
dc.subject	Simulation model	en
dc.subject	Tumor growth	en
dc.subject.other	Computer simulation	en
dc.subject.other	Diffusion	en
dc.subject.other	Histology	en
dc.subject.other	Oncology	en
dc.subject.other	Patient treatment	en
dc.subject.other	Radiotherapy	en
dc.subject.other	Stochastic control systems	en
dc.subject.other	Multicellular spheroid	en
dc.subject.other	Radiosensitivity	en
dc.subject.other	Simulation model	en
dc.subject.other	Tumor growth	en
dc.subject.other	Tumors	en
dc.title	Stochastic modeling and validation of growth saturation and radiotherapeutic response of multicellular tumor spheroids	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2004.1403860	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2004.1403860	en
heal.publicationDate	2004	en
heal.abstract	An advanced three-dimensional (3D) Monte Carlo simulation model of both the avascular development of multicellular tumor spheroids and their response to radiation therapy is presented. The model is based upon a number of fundamental biological principles such as the transition between the cell cycle phases, the diffusion of oxygen and nutrients and the cell survival probabilities following irradiation. Predicted histological structure and tumor growth rates evaluated for the case of EMT6/Ro spheroids have been shown to be in agreement with published experimental data. Furthermore, the underlying structure of the tumor spheroid as well as its response to irradiation satisfactorily agrees with laboratory experience.	en
heal.journalName	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings	en
dc.identifier.doi	10.1109/IEMBS.2004.1403860	en
dc.identifier.volume	26 IV	en
dc.identifier.spage	3039	en
dc.identifier.epage	3042	en