Web service-enabled grid-based platform for drug resistance management

Gouvas, P; Magiorkinis, G; Bouras, A; Paraskevis, D; Alexandrou, D; Hatzakis, A; Mentzas, G

dc.contributor.author	Gouvas, P	en
dc.contributor.author	Magiorkinis, G	en
dc.contributor.author	Bouras, A	en
dc.contributor.author	Paraskevis, D	en
dc.contributor.author	Alexandrou, D	en
dc.contributor.author	Hatzakis, A	en
dc.contributor.author	Mentzas, G	en
dc.date.accessioned	2014-03-01T02:43:46Z
dc.date.available	2014-03-01T02:43:46Z
dc.date.issued	2005	en
dc.identifier.issn	0302-9743	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/31503
dc.subject	Clinical Practice	en
dc.subject	Design and Development	en
dc.subject	Drug Resistance	en
dc.subject	Experimental Procedure	en
dc.subject	Hiv Drug Resistance	en
dc.subject	Multiple Sequence Alignment	en
dc.subject	Nucleotide Sequence	en
dc.subject	Phylogenetic Analysis	en
dc.subject	Research Purpose	en
dc.subject	Software Component	en
dc.subject	Web Service	en
dc.subject.classification	Computer Science, Theory & Methods	en
dc.subject.other	Algorithms	en
dc.subject.other	Error analysis	en
dc.subject.other	Estimation	en
dc.subject.other	Information services	en
dc.subject.other	Mutagenesis	en
dc.subject.other	World Wide Web	en
dc.subject.other	Genotypic resistance interpretation	en
dc.subject.other	Mutation identification	en
dc.subject.other	Phylogenetic analysis	en
dc.subject.other	Web services	en
dc.subject.other	Distributed computer systems	en
dc.title	Web service-enabled grid-based platform for drug resistance management	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1007/11573036_44	en
heal.identifier.secondary	http://dx.doi.org/10.1007/11573036_44	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	HIV Drug Resistance testing has been established as a routine test in several cases. Estimation of genotypic resistance is a laborious task consisting of experimental procedure and complicated algorithmic interpretation of mutational pattern (sequence data). Since the sequencing procedure is not error free, it is often necessary to proceed into quality checking and manual editing of the raw data (chromatograms). This paper presents the design and development of a grid-based platform that assists the storage and analysis of HIV nucleotide sequences both for clinical practice and research purposes. Modular software components were implemented for sequence uploading, quality verification, mutation identification, genotypic resistance interpretation, phylogenetic analysis, multiple-sequence alignment and sophisticated mutation querying. Moreover these services have been exported as web services in order to provide a high layer of abstraction and enhanced collaboration among researchers. The platform has been validated and tested with more than 500 HIV sequences. © Springer-Verlag Berlin Heidelberg 2005.	en
heal.publisher	SPRINGER-VERLAG BERLIN	en
heal.journalName	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)	en
heal.bookName	LECTURE NOTES IN COMPUTER SCIENCE	en
dc.identifier.doi	10.1007/11573036_44	en
dc.identifier.isi	ISI:000233675500044	en
dc.identifier.volume	3746 LNCS	en
dc.identifier.spage	469	en
dc.identifier.epage	479	en