Swelling and hydrolytic degradation of poly(d,l-lactic acid) in aqueous solutions

Proikakis, CS; Mamouzelos, NJ; Tarantili, PA; Andreopoulos, AG

dc.contributor.author	Proikakis, CS	en
dc.contributor.author	Mamouzelos, NJ	en
dc.contributor.author	Tarantili, PA	en
dc.contributor.author	Andreopoulos, AG	en
dc.date.accessioned	2014-03-01T02:44:12Z
dc.date.available	2014-03-01T02:44:12Z
dc.date.issued	2006	en
dc.identifier.issn	0141-3910	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/31749
dc.subject	Degradation	en
dc.subject	Erosion	en
dc.subject	Hydrolysis	en
dc.subject	Poly(d,l-lactic acid)	en
dc.subject	Swelling	en
dc.subject.classification	Polymer Science	en
dc.subject.other	Bacteria	en
dc.subject.other	Carboxylic acids	en
dc.subject.other	Degradation	en
dc.subject.other	Erosion	en
dc.subject.other	Formaldehyde	en
dc.subject.other	Gel permeation chromatography	en
dc.subject.other	Hydrolysis	en
dc.subject.other	Light scattering	en
dc.subject.other	Molecular weight	en
dc.subject.other	Polycondensation	en
dc.subject.other	Porosity	en
dc.subject.other	Solutions	en
dc.subject.other	Swelling	en
dc.subject.other	Synthesis (chemical)	en
dc.subject.other	Viscosity measurement	en
dc.subject.other	Hydrolytic degradation	en
dc.subject.other	Poly(d,1-lactic acid)	en
dc.subject.other	Polymeric matrix	en
dc.subject.other	Tablets	en
dc.subject.other	Organic polymers	en
dc.title	Swelling and hydrolytic degradation of poly(d,l-lactic acid) in aqueous solutions	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1016/j.polymdegradstab.2005.01.060	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.polymdegradstab.2005.01.060	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	Low molecular weight poly(lactic acid) was synthesized by direct polycondensation of lactic acid. The oligomers were characterized by viscometry, light scattering, and gel permeation chromatography (GPC). The swelling behaviour of tablets made of the above polymer immersed in buffer solutions at 37 degrees C was studied. In the same experiments, the hydrolytic stability of D,L-PLA was assessed by measuring the weight loss after drying the tablets. In order to inhibit any degradation due to bacteria, formaldehyde was added in the solution as biostatic factor. The effect of an incorporated drug on the swelling behaviour Of D,L-PLA tablets was also considered. It was found that the incorporation of drug in D,L-PLA tablets increases their swelling index, probably due to the creation of additional porosity in the specimens or other interaction between drug and polymeric matrix. (c) 2005 Elsevier Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI LTD	en
heal.journalName	Polymer Degradation and Stability	en
dc.identifier.doi	10.1016/j.polymdegradstab.2005.01.060	en
dc.identifier.isi	ISI:000234162800029	en
dc.identifier.volume	91	en
dc.identifier.issue	3	en
dc.identifier.spage	614	en
dc.identifier.epage	619	en