A mathematical model of the mechanical deformation of the carotid artery wall and its application to clinical data

Stoitsis, J; Golemati, S; Bastouni, E; Nikita, KS

dc.contributor.author	Stoitsis, J	en
dc.contributor.author	Golemati, S	en
dc.contributor.author	Bastouni, E	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T02:44:23Z
dc.date.available	2014-03-01T02:44:23Z
dc.date.issued	2007	en
dc.identifier.issn	05891019	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/31794
dc.subject	Arterial wall	en
dc.subject	Deformation	en
dc.subject	Modeling	en
dc.subject	Ultrasound	en
dc.subject.other	Image analysis	en
dc.subject.other	Mathematical models	en
dc.subject.other	Mean square error	en
dc.subject.other	Medical imaging	en
dc.subject.other	Ultrasonics	en
dc.subject.other	Waveform analysis	en
dc.subject.other	Carotid artery wall	en
dc.subject.other	Clinical data	en
dc.subject.other	Mechanical deformation	en
dc.subject.other	Root mean square error	en
dc.subject.other	Cardiovascular system	en
dc.title	A mathematical model of the mechanical deformation of the carotid artery wall and its application to clinical data	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2007.4352751	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2007.4352751	en
heal.identifier.secondary	4352751	en
heal.publicationDate	2007	en
heal.abstract	The study of arterial wall mechanics, including the study of stresses and strains experienced by the vascular wall, is pivotal in our understanding of arterial physiology. In this paper, a mathematical model is provided describing the deformation of the arterial wall in terms of 6 parameters. Actual deformation waveforms were also obtained from the analysis of B-mode ultrasound image sequences of the carotid artery using block-matching. The mathematical model was fitted to the clinical data using nonlinear least squares to determine the 6 parameters for 6 different locations along the posterior and 6 along the anterior walls, on the interface between the lumen and the intima-media complex (L-IM). On the posterior wall, 6 locations were also investigated at the interface between the intima-media complex and the adventitia (IM-A) as well as at the adventitia-surrounding tissue (A-T) boundary. The root mean square error was low for all locations indicating a good fit of the proposed model to the clinical data. The amplitude of the deformation, expressed through parameter a, was significantly lower in the A-T interface compared to the other two interfaces. The time when the systolic peak occurs, expressed through parameter t1, was significantly lower in the L-IM interface compared to the other two interfaces. Preliminary findings from a small group of diseased wall locations suggested that the parameters a, b and t1 were significantly different than healthy cases. This probably reflects alterations of arterial wall mechanics due to disease. This study showed that the proposed mathematical model is a satisfactory representation of the mechanical deformation of the carotid artery wall in the radial direction and can provide valuable information in the understanding of the mechanical behavior of the arterial wall. © 2007 IEEE.	en
heal.journalName	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings	en
dc.identifier.doi	10.1109/IEMBS.2007.4352751	en
dc.identifier.volume	2007	en
dc.identifier.spage	2163	en
dc.identifier.epage	2166	en