Nonlinear, multiple-input modeling of cerebral hemodynamics during baseline and hypercapnia in young and post-menopausal women

Mitsis, GD; Debert, CT; Hajo, MI; Marmarelis, VZ; Poulin, MJ

dc.contributor.author	Mitsis, GD	en
dc.contributor.author	Debert, CT	en
dc.contributor.author	Hajo, MI	en
dc.contributor.author	Marmarelis, VZ	en
dc.contributor.author	Poulin, MJ	en
dc.date.accessioned	2014-03-01T02:44:51Z
dc.date.available	2014-03-01T02:44:51Z
dc.date.issued	2007	en
dc.identifier.issn	05891019	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/31981
dc.subject.other	Blood pressure	en
dc.subject.other	Carbon dioxide	en
dc.subject.other	Flow velocity	en
dc.subject.other	Hormones	en
dc.subject.other	Living systems studies	en
dc.subject.other	Mammals	en
dc.subject.other	Autoregulation	en
dc.subject.other	Cerebral circulation	en
dc.subject.other	Multiple-input models	en
dc.subject.other	Hemodynamics	en
dc.title	Nonlinear, multiple-input modeling of cerebral hemodynamics during baseline and hypercapnia in young and post-menopausal women	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2007.4352924	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2007.4352924	en
heal.identifier.secondary	4352924	en
heal.publicationDate	2007	en
heal.abstract	Normal aging is associated with changes in the cardiovascular system and more specifically in cerebral circulation. Sex-dependent changes in cerebrovascular CO2 reactivity, which may be related to hormonal levels, have been also reported. We therefore examined cerebral hemodynamics, i.e., dynamic pressure autoregulation and CO2 reactivity, by employing beat-to-beat values of mean arterial blood pressure and middle cerebral artery blood flow velocity, as well as breath-to-breath values of end-tidal CO2 tension during baseline and sustained, end-tidal forcing induced hypercapnia in pre- and post-menopausal women. For this purpose, we employed a recently proposed nonlinear, multiple-input model of cerebral hemodynamics. The results suggest that dynamic autoregulation and reactivity in response to spontaneous fluctuations are not affected in postmenopausal women and that CO2 reactivity to the larger, experimentally-induced hypercapnic stimuli are affected mildly. A significant decrease in CO 2 reactivity to spontaneous fluctuations was also observed during hypercapnia in all three groups. © 2007 IEEE.	en
heal.journalName	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings	en
dc.identifier.doi	10.1109/IEMBS.2007.4352924	en
dc.identifier.volume	2007	en
dc.identifier.spage	2855	en
dc.identifier.epage	2858	en