Automatic intra-operative localization of STN using the beta band frequencies of microelectrode recordings

Michmizos, KP; Tagaris, GL; Sakas, DE; Nikita, KS

dc.contributor.author	Michmizos, KP	en
dc.contributor.author	Tagaris, GL	en
dc.contributor.author	Sakas, DE	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T02:45:10Z
dc.date.available	2014-03-01T02:45:10Z
dc.date.issued	2008	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32173
dc.subject	Deep Brain Stimulation	en
dc.subject	Oscillations	en
dc.subject	Parkinson Disease	en
dc.subject	Spectral Analysis	en
dc.subject	Subthalamic Nucleus	en
dc.subject	Surgical Treatment	en
dc.subject	Basal Ganglia	en
dc.subject.other	Band frequencies	en
dc.subject.other	Basal ganglia	en
dc.subject.other	Deep brain stimulation	en
dc.subject.other	Frequency ranges	en
dc.subject.other	Intra-operative	en
dc.subject.other	Levodopa	en
dc.subject.other	Microelectrode recording	en
dc.subject.other	Motor fluctuations	en
dc.subject.other	Parkinson disease	en
dc.subject.other	Spectral analysis	en
dc.subject.other	Subthalamic nucleus	en
dc.subject.other	Surgical treatment	en
dc.subject.other	Therapeutic efficacy	en
dc.subject.other	Bioinformatics	en
dc.subject.other	Frequency bands	en
dc.subject.other	Microelectrodes	en
dc.subject.other	Spectrum analysis	en
dc.subject.other	Spectrum analyzers	en
dc.subject.other	Surface defects	en
dc.title	Automatic intra-operative localization of STN using the beta band frequencies of microelectrode recordings	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/BIBE.2008.4696820	en
heal.identifier.secondary	http://dx.doi.org/10.1109/BIBE.2008.4696820	en
heal.identifier.secondary	4696820	en
heal.publicationDate	2008	en
heal.abstract	Deep Brain Stimulation (DBS) is considered a surgical treatment alternative for Parkinson Disease (PD) patients with intractable tremor or for those patients who are affected by long-term complications of levodopa therapy such as motor fluctuations and severe dyskinesias. However, the susceptible accuracy of placement of the DBS electrode inside the brain nucleus determines the therapeutic efficacy of the method. Unlike normal cases, untreated Parkinsonian states in basal ganglia structures produce oscillations at various frequencies, the most prominent of which is a synchronization in the beta frequency band recorded in the Subthalamic Nucleus (STN). The actual frequency range and the strength of the beta peak vary among patients. We propose that an on-line spectral analysis of the population activity, as evidenced by microelectrode recordings (MERs) could form a neurophysiological biomarker for confirmation of the on-target placement of the electrode within the STN.	en
heal.journalName	8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008	en
dc.identifier.doi	10.1109/BIBE.2008.4696820	en