Clinical trial simulation in grid environments

Kyriazis, D; Menychtas, A; Dionysiou, D; Stamatakos, G; Varvarigou, T

dc.contributor.author	Kyriazis, D	en
dc.contributor.author	Menychtas, A	en
dc.contributor.author	Dionysiou, D	en
dc.contributor.author	Stamatakos, G	en
dc.contributor.author	Varvarigou, T	en
dc.date.accessioned	2014-03-01T02:45:11Z
dc.date.available	2014-03-01T02:45:11Z
dc.date.issued	2008	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32186
dc.subject	Clinical Study	en
dc.subject	Clinical Trial	en
dc.subject	Computer Simulation	en
dc.subject	Cost Effectiveness	en
dc.subject	glioblastoma multiforme	en
dc.subject	Historical Data	en
dc.subject.other	Biological science	en
dc.subject.other	Clinical study	en
dc.subject.other	Clinical trial	en
dc.subject.other	Computer simulation model	en
dc.subject.other	Glioblastoma multiforme	en
dc.subject.other	Grid environments	en
dc.subject.other	Grid technologies	en
dc.subject.other	Historical data	en
dc.subject.other	Therapeutic treatments	en
dc.subject.other	Tumour growth	en
dc.subject.other	Bioinformatics	en
dc.subject.other	Grid computing	en
dc.subject.other	Tumors	en
dc.subject.other	Simulators	en
dc.title	Clinical trial simulation in grid environments	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/BIBE.2008.4696659	en
heal.identifier.secondary	http://dx.doi.org/10.1109/BIBE.2008.4696659	en
heal.identifier.secondary	4696659	en
heal.publicationDate	2008	en
heal.abstract	A constantly increasing number of applications from various scientific sectors are finding their way towards adopting Grid technologies in order to take advantage of their capabilities: the advent of Grid environments made feasible the solution of computational intensive problems in a reliable and cost-effective way. The aim of this paper is to demonstrate how multilevel tumour growth and response to therapeutic treatment models can be used in order to simulate clinical trials, with the long-term intention of better designing clinical studies and understanding their outcome based on basic biological science. For this purpose, a computer simulation model of glioblastoma multiforme response to radiotherapy has been applied to perform the aforementioned simulation in a real Grid environment by also taking into account historical data. The proposed approach yields very good results for the conducted virtual trial since these are in agreement with the outcome of the real clinical study, while the use of Grid technologies demonstrate and highlight their added-value.	en
heal.journalName	8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008	en
dc.identifier.doi	10.1109/BIBE.2008.4696659	en