Local hemodynamics and intimal hyperplasia at the venous side of porcine carotid artery - Jugular vein shunt

Manos, TA; Sokolis, DP; Giagini, AT; Davos, CH; Kakisis, JD; Stergiopulos, N; Karayannacos, PE; Tsangaris, S

dc.contributor.author	Manos, TA	en
dc.contributor.author	Sokolis, DP	en
dc.contributor.author	Giagini, AT	en
dc.contributor.author	Davos, CH	en
dc.contributor.author	Kakisis, JD	en
dc.contributor.author	Stergiopulos, N	en
dc.contributor.author	Karayannacos, PE	en
dc.contributor.author	Tsangaris, S	en
dc.date.accessioned	2014-03-01T02:45:32Z
dc.date.available	2014-03-01T02:45:32Z
dc.date.issued	2008	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32301
dc.subject	Boundary Condition	en
dc.subject	Carotid Artery	en
dc.subject	Computation Fluid Dynamics	en
dc.subject	Computer Model	en
dc.subject	Flow Field	en
dc.subject	Flow Rate	en
dc.subject	Numerical Computation	en
dc.subject	Ultrasound	en
dc.subject	Common Carotid Artery	en
dc.subject	Intimal Hyperplasia	en
dc.subject	Internal Jugular Vein	en
dc.subject	Wall Shear Stress	en
dc.subject.other	3D geometry	en
dc.subject.other	Arteriovenous shunt	en
dc.subject.other	Biplane angiographies	en
dc.subject.other	Carotid artery	en
dc.subject.other	Color Doppler	en
dc.subject.other	Commercial codes	en
dc.subject.other	Common carotid artery	en
dc.subject.other	Computational model	en
dc.subject.other	Dean vortex	en
dc.subject.other	Histological examination	en
dc.subject.other	In-vivo	en
dc.subject.other	Input data	en
dc.subject.other	Internal jugular veins	en
dc.subject.other	Intimal hyperplasia	en
dc.subject.other	Intravascular	en
dc.subject.other	Jugular veins	en
dc.subject.other	Local flow field	en
dc.subject.other	Numerical computations	en
dc.subject.other	Ultrasound measurement	en
dc.subject.other	Vessel walls	en
dc.subject.other	Wall shear stress	en
dc.subject.other	Bioinformatics	en
dc.subject.other	Computational fluid dynamics	en
dc.subject.other	Hydrodynamics	en
dc.subject.other	Three dimensional	en
dc.subject.other	Flow fields	en
dc.title	Local hemodynamics and intimal hyperplasia at the venous side of porcine carotid artery - Jugular vein shunt	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/BIBE.2008.4696814	en
heal.identifier.secondary	http://dx.doi.org/10.1109/BIBE.2008.4696814	en
heal.identifier.secondary	4696814	en
heal.publicationDate	2008	en
heal.abstract	One of the chief factors, incriminated for the formation of intimal hyperplasia at the venous side of an arteriovenous shunt (AVS), is the disturbed hemodynamic conditionccin that region. Owing to the difficulty of properly measuring the local flow field in AVS, numerical computation has been extensively used for its assessment. The purpose of this study was to examine the flow field in AVS with computational fluid dynamics (CFD). AVS was created in a pig between the common carotid artery and the internal jugular vein using an ePTFE graft. Input data to the computational model was obtained in vivo one month later, and adjacent vessels were excised and submitted to histological examination. The 3D geometry of the shunt was determined using biplane angiography. Ultrasound measurements of the flow rates were performed with perivascular flow probes. Pressures were recorded using intravascular catheters. This data was used as boundary conditions in the commercial code FLUENT® for calculation of the flow field. Our numerical findings are suggestive of strong Dean vortices towards both vein flow exits, verified by color Doppler. The high wall shear stresses that accompany these vortices are related to areas of intimal hyperplasia, as evidenced in preliminary histological studies of the venous vessel wall.	en
heal.journalName	8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008	en
dc.identifier.doi	10.1109/BIBE.2008.4696814	en