Modeling of regional dynamic CO2 reactivity in respiratory related brain areas using BOLD fMRI

Mitsis, GD; Harvey, AK; Dirckx, S; Mayhew, SD; Rogers, R; Tracey, I; Wise, RG; Pattinson, KTS

dc.contributor.author	Mitsis, GD	en
dc.contributor.author	Harvey, AK	en
dc.contributor.author	Dirckx, S	en
dc.contributor.author	Mayhew, SD	en
dc.contributor.author	Rogers, R	en
dc.contributor.author	Tracey, I	en
dc.contributor.author	Wise, RG	en
dc.contributor.author	Pattinson, KTS	en
dc.date.accessioned	2014-03-01T02:45:37Z
dc.date.available	2014-03-01T02:45:37Z
dc.date.issued	2008	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32310
dc.subject	Experimental Measurement	en
dc.subject	Functional Magnetic Resonance Images	en
dc.subject	Impulse Response	en
dc.subject	Regional Difference	en
dc.subject	Spontaneous Breathing	en
dc.subject.other	Brain areas	en
dc.subject.other	Brainstem	en
dc.subject.other	Dynamic effects	en
dc.subject.other	Dynamic reactivity	en
dc.subject.other	Experimental measurements	en
dc.subject.other	Functional magnetic resonance imaging	en
dc.subject.other	In-vivo	en
dc.subject.other	Regional dynamics	en
dc.subject.other	Spontaneous breathing	en
dc.subject.other	Tidal forcing	en
dc.subject.other	Volterra model	en
dc.subject.other	Bioinformatics	en
dc.subject.other	Impulse response	en
dc.subject.other	Magnetic resonance imaging	en
dc.subject.other	Signal systems	en
dc.subject.other	Brain	en
dc.title	Modeling of regional dynamic CO2 reactivity in respiratory related brain areas using BOLD fMRI	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/BIBE.2008.4696667	en
heal.identifier.secondary	4696667	en
heal.identifier.secondary	http://dx.doi.org/10.1109/BIBE.2008.4696667	en
heal.publicationDate	2008	en
heal.abstract	The cerebrovascular bed is very sensitive to CO2 changes, particularly the areas responsible for generation and control of respiratory rhythm. We have used BOLD functional magnetic resonance imaging (fMRI) and externally induced CO2 challenges that stimulate respiration, to identify respiratory areas in-vivo in humans and to quantify the dynamic effects of CO2 on the BOLD fMRI signal (dynamic CO2 reactivity). We sought to identify regional differences in dynamic reactivity within the brainstem and other respiratory related areas (thalamus) by using linear impulse response (IR) and nonlinear Volterra models, as well as experimental measurements obtained during spontaneous breathing and larger externally induced step CO2 changes (end-tidal forcing). The results revealed areas in the brainstem and thalamus that responded strongly to the external CO 2 stimuli, which correspond to respiratory nuclei identified in recent rodent studies, as well as pronounced regional differences in CO 2 reactivity.	en
heal.journalName	8th IEEE International Conference on BioInformatics and BioEngineering, BIBE 2008	en
dc.identifier.doi	10.1109/BIBE.2008.4696667	en