System sensitivity in preclinical small animal imaging

Chatziioannou, AF; Bao, Q; Karakatsanis, N

dc.contributor.author	Chatziioannou, AF	en
dc.contributor.author	Bao, Q	en
dc.contributor.author	Karakatsanis, N	en
dc.date.accessioned	2014-03-01T02:45:48Z
dc.date.available	2014-03-01T02:45:48Z
dc.date.issued	2008	en
dc.identifier.uri	http://hdl.handle.net/123456789/32402
dc.subject	Preclinical PET	en
dc.subject	Small animal imaging	en
dc.subject	System sensitivity	en
dc.subject.other	Atoms	en
dc.subject.other	Computer networks	en
dc.subject.other	Diagnostic radiography	en
dc.subject.other	Light emission	en
dc.subject.other	Luminescence	en
dc.subject.other	Medical imaging	en
dc.subject.other	Monte Carlo methods	en
dc.subject.other	Positron annihilation spectroscopy	en
dc.subject.other	Scintillation counters	en
dc.subject.other	Technical presentations	en
dc.subject.other	Tomography	en
dc.subject.other	International symposium	en
dc.subject.other	Preclinical PET	en
dc.subject.other	Scintillator materials	en
dc.subject.other	Small animal imaging	en
dc.subject.other	System sensitivity	en
dc.subject.other	Positron emission tomography	en
dc.title	System sensitivity in preclinical small animal imaging	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/ISBI.2008.4541272	en
heal.identifier.secondary	http://dx.doi.org/10.1109/ISBI.2008.4541272	en
heal.identifier.secondary	4541272	en
heal.publicationDate	2008	en
heal.abstract	Preclinical small animal imaging is an important tool at the disposition of biological researchers. While the range of studies performed by non-invasive preclinical imaging is greatly varied, high sensitivity is of key importance in any biological experiment with molecular imaging probes. The technologies that are used to achieve high system sensitivity mostly focus on the use of large solid angles and dense scintillator materials. In this work, we investigate and discuss different preclinical Positron Emission Tomography system designs and the effects of these designs on the overall sensitivity. We focus our investigations in hypothetical system geometries and scintillator materials and perform Monte Carlo simulations. The results indicate that preclinical PET systems based on detector materials that have minimal intrinsic background and higher effective atomic number, might offer performance advantages for situations where the weakest signal possible needs to be detected. ©2008 IEEE.	en
heal.journalName	2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI	en
dc.identifier.doi	10.1109/ISBI.2008.4541272	en
dc.identifier.spage	1417	en
dc.identifier.epage	1420	en