System sensitivity in preclinical small animal imaging

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dc.contributor.author Chatziioannou, AF en
dc.contributor.author Bao, Q en
dc.contributor.author Karakatsanis, N en
dc.date.accessioned 2014-03-01T02:45:48Z
dc.date.available 2014-03-01T02:45:48Z
dc.date.issued 2008 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/32402
dc.subject Preclinical PET en
dc.subject Small animal imaging en
dc.subject System sensitivity en
dc.subject.other Atoms en
dc.subject.other Computer networks en
dc.subject.other Diagnostic radiography en
dc.subject.other Light emission en
dc.subject.other Luminescence en
dc.subject.other Medical imaging en
dc.subject.other Monte Carlo methods en
dc.subject.other Positron annihilation spectroscopy en
dc.subject.other Scintillation counters en
dc.subject.other Technical presentations en
dc.subject.other Tomography en
dc.subject.other International symposium en
dc.subject.other Preclinical PET en
dc.subject.other Scintillator materials en
dc.subject.other Small animal imaging en
dc.subject.other System sensitivity en
dc.subject.other Positron emission tomography en
dc.title System sensitivity in preclinical small animal imaging en
heal.type conferenceItem en
heal.identifier.primary 10.1109/ISBI.2008.4541272 en
heal.identifier.secondary http://dx.doi.org/10.1109/ISBI.2008.4541272 en
heal.identifier.secondary 4541272 en
heal.publicationDate 2008 en
heal.abstract Preclinical small animal imaging is an important tool at the disposition of biological researchers. While the range of studies performed by non-invasive preclinical imaging is greatly varied, high sensitivity is of key importance in any biological experiment with molecular imaging probes. The technologies that are used to achieve high system sensitivity mostly focus on the use of large solid angles and dense scintillator materials. In this work, we investigate and discuss different preclinical Positron Emission Tomography system designs and the effects of these designs on the overall sensitivity. We focus our investigations in hypothetical system geometries and scintillator materials and perform Monte Carlo simulations. The results indicate that preclinical PET systems based on detector materials that have minimal intrinsic background and higher effective atomic number, might offer performance advantages for situations where the weakest signal possible needs to be detected. ©2008 IEEE. en
heal.journalName 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI en
dc.identifier.doi 10.1109/ISBI.2008.4541272 en
dc.identifier.spage 1417 en
dc.identifier.epage 1420 en

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