Towards input output non-linear modeling of the subthalamic nucleus using intranuclear recordings

Michmizos, KP; Nikita, KS; Tagaris, GL; Sakas, DE

dc.contributor.author	Michmizos, KP	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Tagaris, GL	en
dc.contributor.author	Sakas, DE	en
dc.date.accessioned	2014-03-01T02:46:34Z
dc.date.available	2014-03-01T02:46:34Z
dc.date.issued	2009	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32719
dc.subject	Input output model	en
dc.subject	Intranuclear recordings	en
dc.subject	Subthalamic nucleus	en
dc.subject.other	Basal ganglia	en
dc.subject.other	Deep brain stimulation	en
dc.subject.other	Hammerstein-Wiener models	en
dc.subject.other	Input output model	en
dc.subject.other	Input-output	en
dc.subject.other	Input-output systems	en
dc.subject.other	Intranuclear recordings	en
dc.subject.other	Local field potentials	en
dc.subject.other	Non-linear	en
dc.subject.other	Nonlinear modeling	en
dc.subject.other	Parkinsonian tremor	en
dc.subject.other	Reasonable accuracy	en
dc.subject.other	Subthalamic nucleus	en
dc.title	Towards input output non-linear modeling of the subthalamic nucleus using intranuclear recordings	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/NER.2009.5109368	en
heal.identifier.secondary	http://dx.doi.org/10.1109/NER.2009.5109368	en
heal.identifier.secondary	5109368	en
heal.publicationDate	2009	en
heal.abstract	The subthalamic nucleus (STN) is a pivotal point of the basal ganglia function and dysfunction. Its crucial engagement with the neurosurgical procedure of deep brain stimulation (DBS) that alleviates medically intractable Parkinsonian tremor augments the need to refine our current understanding of it. Intranuclear recordings, received from a patient during surgery, are processed to acquire both local field potentials (LFPs) and the spiking activity of the cells inside the nucleus. Under the physiologically justified assumption that the LFPs constitute the input of the cells inside the nucleus whereas the spikes are the output, an input output system analysis of the STN is straightforward. Primary results show that a non-linear Hammerstein-Wiener model is able to simulate the STN output with a reasonable accuracy. ©2009 IEEE.	en
heal.journalName	2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09	en
dc.identifier.doi	10.1109/NER.2009.5109368	en
dc.identifier.spage	601	en
dc.identifier.epage	604	en