Can we infer subthalamic nucleus spike trains from intranuclear local field potentials?

Michmizos, KP; Nikita, KS

dc.contributor.author	Michmizos, KP	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T02:46:42Z
dc.date.available	2014-03-01T02:46:42Z
dc.date.issued	2010	en
dc.identifier.issn	1557170X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32800
dc.subject	Deep Brain Stimulation	en
dc.subject	Local Field Potential	en
dc.subject	Spike Train	en
dc.subject	Subthalamic Nucleus	en
dc.subject	Basal Ganglia	en
dc.subject.other	Basal ganglia	en
dc.subject.other	Deep brain stimulation	en
dc.subject.other	Hammerstein-Wiener models	en
dc.subject.other	Local field potentials	en
dc.subject.other	Spike train	en
dc.subject.other	Subthalamic nucleus	en
dc.subject.other	Surgery	en
dc.subject.other	Forecasting	en
dc.title	Can we infer subthalamic nucleus spike trains from intranuclear local field potentials?	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2010.5626523	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2010.5626523	en
heal.identifier.secondary	5626523	en
heal.publicationDate	2010	en
heal.abstract	The subthalamic nucleus (STN) is one of the subcortical nuclei that constitute the basal ganglia and a pivotal point of their function and dysfunction. In this paper, we use intranuclear recordings, acquired intraoperatively during deep brain stimulation procedure, to investigate whether it is possible to infer STN spike trains using only the underlying local field potentials (LFPs). We regard the LFPs to be the input and the spikes to be the output of a simple Hammerstein- Wiener model and we show that STN spikes can indeed be inferred from intranuclear LFPs, at least with moderate success. Our model, although not always reliable when predicting exact spike positions, shows a good accuracy in predicting the up to 1 kHz structure in STN spike trains. Hence, intranuclear LFPs can indeed hold useful information for predicting STN spiking activity. © 2010 IEEE.	en
heal.journalName	2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10	en
dc.identifier.doi	10.1109/IEMBS.2010.5626523	en
dc.identifier.volume	2010	en
dc.identifier.spage	5476	en
dc.identifier.epage	5479	en