Investigating the uniqueness of peptides in human signal and bioactive peptides

Alexandridou, A; Tsangaris, GTh; Nikita, K; Spyrou, GM

dc.contributor.author	Alexandridou, A	en
dc.contributor.author	Tsangaris, GTh	en
dc.contributor.author	Nikita, K	en
dc.contributor.author	Spyrou, GM	en
dc.date.accessioned	2014-03-01T02:46:51Z
dc.date.available	2014-03-01T02:46:51Z
dc.date.issued	2010	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32894
dc.subject	Amino Acid Sequence	en
dc.subject	Computer Analysis	en
dc.subject	Signal Peptide	en
dc.subject	Web Service	en
dc.subject	Molecular Mass	en
dc.subject.other	Amino acid sequence	en
dc.subject.other	Bioactive peptides	en
dc.subject.other	Biological mechanisms	en
dc.subject.other	Computational analysis	en
dc.subject.other	Data sets	en
dc.subject.other	Human proteome	en
dc.subject.other	Peptide sequences	en
dc.subject.other	Protein digestion	en
dc.subject.other	Protein identification	en
dc.subject.other	Proteomes	en
dc.subject.other	Proteomics	en
dc.subject.other	Signal peptide	en
dc.subject.other	Amino acids	en
dc.subject.other	Hydrogels	en
dc.subject.other	Information technology	en
dc.subject.other	Molecular biology	en
dc.subject.other	Molecular mass	en
dc.subject.other	Web services	en
dc.subject.other	Peptides	en
dc.title	Investigating the uniqueness of peptides in human signal and bioactive peptides	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/ITAB.2010.5687617	en
heal.identifier.secondary	http://dx.doi.org/10.1109/ITAB.2010.5687617	en
heal.identifier.secondary	5687617	en
heal.publicationDate	2010	en
heal.abstract	The identification of unknown amino acid sequences of peptides as well as protein identification is of great significance in proteomics. Measured molecular masses from protein digestion techniques or from MSIMS analysis open the gates of proteome computational analysis. The uniqueness of a measured molecular mass or a peptide sequence plays a very important role in the fields of protein identification and peptide/protein-biomarker investigation. Furthermore, the property of uniqueness may give insights in the investigation of biological mechanisms. Here we present the application of two computational proteomics web services that we have developed in the investigation of uniqueness of peptides in two data sets of specific interest: The human signal peptide database and a set of published human bioactive peptides. It turns out that all of them are unique in the human proteome and furthermore, in their vast majority they are unique in human when searching across all species. © 2010 IEEE.	en
heal.journalName	Proceedings of the IEEE/EMBS Region 8 International Conference on Information Technology Applications in Biomedicine, ITAB	en
dc.identifier.doi	10.1109/ITAB.2010.5687617	en