Sensitivity investigations of surface stress capacitive DNA sensor

Chatzandroulis, S; Tsouti, V; Gousrouridis, D; Normand, P; Boutopoulos, C; Zergioti, I; Tsoukalas, D; Ioannou, M; Kafetzopoulos, D; Hue, J; Rousier, R

dc.contributor.author	Chatzandroulis, S	en
dc.contributor.author	Tsouti, V	en
dc.contributor.author	Gousrouridis, D	en
dc.contributor.author	Normand, P	en
dc.contributor.author	Boutopoulos, C	en
dc.contributor.author	Zergioti, I	en
dc.contributor.author	Tsoukalas, D	en
dc.contributor.author	Ioannou, M	en
dc.contributor.author	Kafetzopoulos, D	en
dc.contributor.author	Hue, J	en
dc.contributor.author	Rousier, R	en
dc.date.accessioned	2014-03-01T02:46:59Z
dc.date.available	2014-03-01T02:46:59Z
dc.date.issued	2010	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/32971
dc.subject	Surface Stress	en
dc.subject.other	Biological interactions	en
dc.subject.other	Biological targets	en
dc.subject.other	Biosensing elements	en
dc.subject.other	Biosensor arrays	en
dc.subject.other	Capacitive type	en
dc.subject.other	DNA sensors	en
dc.subject.other	matrix	en
dc.subject.other	Sample concentration	en
dc.subject.other	Sensing elements	en
dc.subject.other	Surface stress	en
dc.subject.other	Oligonucleotides	en
dc.subject.other	Polymerase chain reaction	en
dc.subject.other	Surface properties	en
dc.subject.other	Biosensors	en
dc.title	Sensitivity investigations of surface stress capacitive DNA sensor	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/ICSENS.2010.5690309	en
heal.identifier.secondary	http://dx.doi.org/10.1109/ICSENS.2010.5690309	en
heal.identifier.secondary	5690309	en
heal.publicationDate	2010	en
heal.abstract	Investigations of the sensitivity and selectivity of a capacitive type biosensor array, consisting of a total of 256 biosensing elements, in the detection of single oligonucleotide mutations is presented. The biosensor takes advantage of surface stress changes during biological interactions and is able to translate them into a capacitive signal. The array is organized in a 16x16 matrix of distinct biosensing elements thus allowing for the concurrent sensing of multiple biological targets. In this work the sensing elements of the array are spotted with three different oligonucleotides (CD8, CD17 and CD19) and their hybridization is detected using 36nM PCR. Moreover tests with CD19 revealed the ability of the biosensor to detect the hybridization of the oligo with sample concentrations of 36, 18 and 9nM. ©2010 IEEE.	en
heal.journalName	Proceedings of IEEE Sensors	en
dc.identifier.doi	10.1109/ICSENS.2010.5690309	en
dc.identifier.spage	1554	en
dc.identifier.epage	1557	en