Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron

Michmizos, KP; Nikita, KS

dc.contributor.author	Michmizos, KP	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T02:47:16Z
dc.date.available	2014-03-01T02:47:16Z
dc.date.issued	2011	en
dc.identifier.issn	1557170X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/33042
dc.subject.other	Deep brain stimulation	en
dc.subject.other	Extracellular	en
dc.subject.other	Firing patterns	en
dc.subject.other	Firing rates	en
dc.subject.other	Local field potentials	en
dc.subject.other	Microelectrode recording	en
dc.subject.other	Neuronal activities	en
dc.subject.other	Parkinsonian tremor	en
dc.subject.other	Subthalamic nucleus	en
dc.subject.other	Electrophysiology	en
dc.subject.other	Equipment testing	en
dc.subject.other	Microelectrodes	en
dc.subject.other	Neurosurgery	en
dc.title	Addition of deep brain stimulation signal to a local field potential driven Izhikevich model masks the pathological firing pattern of an STN neuron	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2011.6091700	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2011.6091700	en
heal.identifier.secondary	6091700	en
heal.publicationDate	2011	en
heal.abstract	The crucial engagement of the subthalamic nucleus (STN) with the neurosurgical procedure of deep brain stimulation (DBS) that alleviates medically intractable Parkinsonian tremor augments the need to refine our current understanding of STN. To enhance the efficacy of DBS as a result of precise targeting, STN boundaries are accurately mapped using extracellular microelectrode recordings (MERs). We utilized the intranuclear MER to acquire the local field potential (LFP) and drive an Izhikevich model of an STN neuron. Using the model as the test bed for clinically acquired data, we demonstrated that stimulation of the STN neuron produces excitatory responses that tonically increase its average firing rate and alter the pattern of its neuronal activity. We also found that the spiking rhythm increases linearly with the increase of amplitude, frequency, and duration of the DBS pulse, inside the clinical range. Our results are in agreement with the current hypothesis that DBS increases the firing rate of STN and masks its pathological bursting firing pattern. © 2011 IEEE.	en
heal.journalName	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS	en
dc.identifier.doi	10.1109/IEMBS.2011.6091700	en
dc.identifier.volume	2011	en
dc.identifier.spage	7290	en
dc.identifier.epage	7293	en