Modeling signaling pathways in articular cartilage

Melas, IN; Chairakaki, AD; Mitsos, A; Dailiana, Z; Provatidis, CG; Alexopoulos, LG

dc.contributor.author	Melas, IN	en
dc.contributor.author	Chairakaki, AD	en
dc.contributor.author	Mitsos, A	en
dc.contributor.author	Dailiana, Z	en
dc.contributor.author	Provatidis, CG	en
dc.contributor.author	Alexopoulos, LG	en
dc.date.accessioned	2014-03-01T02:47:25Z
dc.date.available	2014-03-01T02:47:25Z
dc.date.issued	2011	en
dc.identifier.issn	1557170X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/33129
dc.subject.other	Articular cartilages	en
dc.subject.other	Cartilage extracellular matrixes	en
dc.subject.other	Cell types	en
dc.subject.other	Chondrocytes	en
dc.subject.other	High throughput	en
dc.subject.other	Joint disease	en
dc.subject.other	Optimization algorithms	en
dc.subject.other	Predictive models	en
dc.subject.other	Shedding light	en
dc.subject.other	Signaling networks	en
dc.subject.other	Signaling pathways	en
dc.subject.other	Signaling transduction	en
dc.subject.other	State of the art	en
dc.subject.other	Algorithms	en
dc.subject.other	Arts computing	en
dc.subject.other	Body fluids	en
dc.subject.other	Signaling	en
dc.subject.other	Cartilage	en
dc.title	Modeling signaling pathways in articular cartilage	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1109/IEMBS.2011.6090630	en
heal.identifier.secondary	http://dx.doi.org/10.1109/IEMBS.2011.6090630	en
heal.identifier.secondary	6090630	en
heal.publicationDate	2011	en
heal.abstract	Chondrocytes, the only cell type in articular cartilage, are responsible for maintaining the composition of cartilage extracellular matrix (ECM) through a complex interplay of anabolic and catabolic stimuli. Although understanding the way chondrocytes respond to stimuli is of utmost importance for shedding light into the etiology of joint diseases, an integrative approach to studying their signaling transduction mechanisms is yet to be introduced. Herein, we propose an approach that combines high throughput proteomic measurements and state of the art optimization algorithms to construct a predictive model of chondrocyte signaling network, downstream of 78 receptors of interest. © 2011 IEEE.	en
heal.journalName	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS	en
dc.identifier.doi	10.1109/IEMBS.2011.6090630	en
dc.identifier.volume	2011	en
dc.identifier.spage	3712	en
dc.identifier.epage	3715	en