Influence of drug and light dose in determining PDT efficacy in human pancreatic cancer cells, treated with zinc tetrasulfonated phthalocyanines (ZnTSPc)

Halkiotis, KN; Uzunoglu, NK; Loukas, S; Pantelias, GE; Trafalis, D; Yova, D

dc.contributor.author	Halkiotis, KN	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Loukas, S	en
dc.contributor.author	Pantelias, GE	en
dc.contributor.author	Trafalis, D	en
dc.contributor.author	Yova, D	en
dc.date.accessioned	2014-03-01T02:48:33Z
dc.date.available	2014-03-01T02:48:33Z
dc.date.issued	1997	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/33887
dc.subject	Diode laser	en
dc.subject	Pancreatic cancer cells	en
dc.subject	PDT	en
dc.subject	Zinc tetrasulfonated phthalocyanines	en
dc.subject.other	Cell culture	en
dc.subject.other	Chemotherapy	en
dc.subject.other	Drug therapy	en
dc.subject.other	Irradiation	en
dc.subject.other	Lasers	en
dc.subject.other	Light	en
dc.subject.other	Light sources	en
dc.subject.other	Lighting	en
dc.subject.other	Optical materials	en
dc.subject.other	Photosensitizers	en
dc.subject.other	Plasmons	en
dc.subject.other	Zinc	en
dc.subject.other	Cell lines	en
dc.subject.other	Diode laser	en
dc.subject.other	Diode lasers	en
dc.subject.other	Illumination sources	en
dc.subject.other	Laser lights	en
dc.subject.other	Pancreatic cancer cells	en
dc.subject.other	Pancreatic cancers	en
dc.subject.other	PDT	en
dc.subject.other	Tetrasulfonated phthalocyanines	en
dc.subject.other	Treatment modalities	en
dc.subject.other	Photodynamic therapy	en
dc.title	Influence of drug and light dose in determining PDT efficacy in human pancreatic cancer cells, treated with zinc tetrasulfonated phthalocyanines (ZnTSPc)	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1117/12.297811	en
heal.identifier.secondary	http://dx.doi.org/10.1117/12.297811	en
heal.publicationDate	1997	en
heal.abstract	Photodynamic Therapy (PDT) has the potential to be applied as an adjuvant treatment modality in advanced cancer cases and recently its role in the management of pancreatic cancer, has been evaluated. Nevertheless PDT remains an experimental therapy and one of the main reasons is its complexity, as far as it relies on the combined action of the photosensitising drug and light source. In this study was evaluated the effect of various photosensitizer and photoirradiation doses, in the lethality of MIA PaCa cell line by using ZnPcS4 as photosensitizer and a novel diode laser system as illumination source. No lethality was observed when only laser light or only photosensitizer was applied to cells. Cells treated with various concentrations of ZnTSPc and a light dose of 9 J/cm2 indicated more than 70% lethality, 24 hrs after irradiation and with a light dose of 6 J/cm2 presented almost 90% lethality, 72 hrs after irradiation. The results show that low light and photosensitizer (drug) doses are enough to obtain lethality of more than 90% of MIA PaCa cells.	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.doi	10.1117/12.297811	en
dc.identifier.volume	3191	en
dc.identifier.spage	243	en
dc.identifier.epage	252	en