Perillyl Alcohol Attenuates in vitro Angiogenesis, Modulates Angiogenic Factor Production and Inhibits Cell Proliferation and Survival in Endothelial and Tumour Cells

Loutrari, H; Skouridou, V; Kolisis, FN; Roussos, C; Papapetropoulos, A

dc.contributor.author	Loutrari, H	en
dc.contributor.author	Skouridou, V	en
dc.contributor.author	Kolisis, FN	en
dc.contributor.author	Roussos, C	en
dc.contributor.author	Papapetropoulos, A	en
dc.date.accessioned	2014-03-01T02:49:53Z
dc.date.available	2014-03-01T02:49:53Z
dc.date.issued	2004	en
dc.identifier.issn	10116583	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/34764
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-1542350112&partnerID=40&md5=4b5f02c3edfd1c45a02f466e209458c0	en
dc.subject.other	angiogenic factor	en
dc.subject.other	angiopoietin 2	en
dc.subject.other	mitogen activated protein kinase 1	en
dc.subject.other	perillyl alcohol	en
dc.subject.other	phorbol 13 acetate 12 myristate	en
dc.subject.other	protein kinase B	en
dc.subject.other	vasculotropin	en
dc.subject.other	angiogenesis	en
dc.subject.other	animal cell	en
dc.subject.other	apoptosis	en
dc.subject.other	cattle	en
dc.subject.other	cell proliferation	en
dc.subject.other	cell strain K 562	en
dc.subject.other	cell survival	en
dc.subject.other	conference paper	en
dc.subject.other	endothelium cell	en
dc.subject.other	enzyme phosphorylation	en
dc.subject.other	human	en
dc.subject.other	human cell	en
dc.subject.other	nonhuman	en
dc.subject.other	protein expression	en
dc.title	Perillyl Alcohol Attenuates in vitro Angiogenesis, Modulates Angiogenic Factor Production and Inhibits Cell Proliferation and Survival in Endothelial and Tumour Cells	en
heal.type	conferenceItem	en
heal.publicationDate	2004	en
heal.abstract	Anti-angiogenic therapy is one of the most promising approaches to control cancer. In this work we studied the effects of perillyl alcohol (POH), a dietary monoterpene with in vivo anti-cancer activity on in vitro angiogenesis, expression of angiogenic ligands and cell proliferation/apoptosis using endothelial and tumour cells. We have shown that POH attenuates the capillary-like organization of cultured endothelial cells, decreases the expression of vascular endothelial growth factor (VEGF) by cancer cells, increases the expression of Angiopoietin 2 (Ang2) by endothelial cells and inhibits cell proliferation and survival in both cell types. We have also demonstrated that POH inhibits the phosphorylation of two key signaling molecules: Akt in endothelial cells and Erk1/2 in cancer cells.	en
heal.journalName	Review of Clinical Pharmacology and Pharmacokinetics, International Edition	en
dc.identifier.volume	18	en
dc.identifier.issue	1	en
dc.identifier.spage	30	en
dc.identifier.epage	32	en