Kubelka-Munk theory based diagnostic algorithms to discriminate healthy and atherosclerotic animal model aorta

Gorpas, DS; Alexandratou, E; Politopoulos, K; Yova, D

dc.contributor.author	Gorpas, DS	en
dc.contributor.author	Alexandratou, E	en
dc.contributor.author	Politopoulos, K	en
dc.contributor.author	Yova, D	en
dc.date.accessioned	2014-03-01T02:50:08Z
dc.date.available	2014-03-01T02:50:08Z
dc.date.issued	2005	en
dc.identifier.issn	16057422	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/34912
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-28844461641&partnerID=40&md5=aa3095534a435e1303eda04f8f571fbd	en
dc.subject	Atherosclerosis	en
dc.subject	Diffuse spectroscopy	en
dc.subject	Kubelka-Munk Model	en
dc.subject	Multivariate statistics	en
dc.subject	Tissue optical properties	en
dc.subject.other	Absorption	en
dc.subject.other	Algorithms	en
dc.subject.other	Histology	en
dc.subject.other	Scattering	en
dc.subject.other	Atherosclerotic aorta	en
dc.subject.other	Diffuse spectroscopy	en
dc.subject.other	Histopathology	en
dc.subject.other	Kubelka-Munk Model	en
dc.subject.other	Tissue optical properties	en
dc.subject.other	Diagnostic products	en
dc.title	Kubelka-Munk theory based diagnostic algorithms to discriminate healthy and atherosclerotic animal model aorta	en
heal.type	conferenceItem	en
heal.identifier.secondary	586212	en
heal.publicationDate	2005	en
heal.abstract	The scope of this work was to determine the Kubelka-Munk scattering and absorption coefficients of healthy and atherosclerotic animal model aorta, from 200 to 1100 nm. Furthermore, using the measured and calculated optical properties, special algorithms were developed in order to discriminate healthy from diseased aorta. Diffuse reflectance and total transmittance were measured via a dual beam diffuse reflectance spectrometer. Inverse Kubelka-Munk Model was applied to calculate the diffusion scattering and absorption coefficients. Diffuse absorption coefficients varied from ∼ 200 cm-1 at 300 nm to ∼ 3 cm-1 at 1100 nm. Kubelka-Munk scattering coefficients ranged from ∼ 100 cm-1 at 200 nm to ∼ 6 cm-1 at 1100 nm. Appropriate discrimination algorithms were developed in order to characterize a specimen as healthy or atherosclerotic. The first algorithm was based on the ratio of diffuse reflectance to the reflectance in infinity. The gradient of this ratio at 390 and 440 nm effectively separated healthy from atherosclerotic aorta. The discrimination between the two groups was succeeded using multivariate statistical analysis and verified by histopathology. The second discrimination algorithm was based on the ratio of diffuse reflectance to the baseline reflectance of each specimen. Effective discrimination of healthy and atherosclerotic aorta was achieved at 370 and 500 nm. © 2005 SPIE-OSA.	en
heal.journalName	Progress in Biomedical Optics and Imaging - Proceedings of SPIE	en
dc.identifier.volume	5862	en
dc.identifier.spage	1	en
dc.identifier.epage	9	en