Photodynamic therapy of murine non-melanoma skin carcinomas with diode laser after topical application of aluminum phthalocyanine chloride

Kyriazi, M; Alexandratou, E; Yova, D; Rallis, M; Trebst, T

dc.contributor.author	Kyriazi, M	en
dc.contributor.author	Alexandratou, E	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Rallis, M	en
dc.contributor.author	Trebst, T	en
dc.date.accessioned	2014-03-01T02:51:09Z
dc.date.available	2014-03-01T02:51:09Z
dc.date.issued	2007	en
dc.identifier.issn	16057422	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/35407
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-36248949754&partnerID=40&md5=fc31749e575c14378230ca81f0ba990e	en
dc.subject	Aluminum phthalocyanine chloride	en
dc.subject	Non melanoma skin carcinomas	en
dc.subject	Photodynamic therapy	en
dc.subject	Topical administration	en
dc.subject.other	Oncology	en
dc.subject.other	Pharmacokinetics	en
dc.subject.other	Photosensitizers	en
dc.subject.other	Semiconductor lasers	en
dc.subject.other	Skin	en
dc.subject.other	Aluminum phthalocyanine chloride	en
dc.subject.other	Non melanoma skin carcinomas	en
dc.subject.other	Skin carcinomas	en
dc.subject.other	Topical administration	en
dc.subject.other	Photodynamic therapy	en
dc.title	Photodynamic therapy of murine non-melanoma skin carcinomas with diode laser after topical application of aluminum phthalocyanine chloride	en
heal.type	conferenceItem	en
heal.identifier.secondary	66320W	en
heal.publicationDate	2007	en
heal.abstract	The aim of this work is to study pharmacokinetics and photodynamic efficiency of aluminium phthalocyanine chloride (AlClPc) in dimethylsulfoxide/ Tween 80/water solution, after topical application on hairless mice bearing non-melanoma skin carcinomas. The concentration of photosensitizer in normal skin and tumor biopsies 1-6 hours after application was assessed by fluorescence spectroscopy of chemical extractions. The concentration of photosensitizer was 40 times higher in tumor than in normal skin even 1 h after application. For photodynamic therapy (PDT) AlClPc was excited by a diode laser emitting at 670 nm, 1 h after application. Seven different combinations of therapeutic parameters were chosen. The efficiency was assessed as the percentage of complete tumor remission, the tumor growth retardation and the cosmetic outcomes. The highest complete remission 60% was achieved with the combination of 75 mW/cm2 with 150 J/cm2. No recurrence rate was observed in any treatment parameters group and the cosmetic outcome in all completely treated tumors was excellent. The results show that the effectiveness of PDT is highly dependent on fluence rate. In addition, they are promising for further investigation of this PDT scheme in preclinical studies mainly in non-melanoma skin carcinomas up to 7mm. © 2007 SPIE-OSA.	en
heal.journalName	Progress in Biomedical Optics and Imaging - Proceedings of SPIE	en
dc.identifier.volume	6632	en