Biophotonics in diagnosis and modeling of tissue pathologies

Serafetinides, AA; Makropoulou, M; Drakaki, E

dc.contributor.author	Serafetinides, AA	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Drakaki, E	en
dc.date.accessioned	2014-03-01T02:51:34Z
dc.date.available	2014-03-01T02:51:34Z
dc.date.issued	2008	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/35559
dc.subject.other	Applications	en
dc.subject.other	Coherent light	en
dc.subject.other	Diagnostic radiography	en
dc.subject.other	Electron optics	en
dc.subject.other	Fluorescence	en
dc.subject.other	Histology	en
dc.subject.other	Laser produced plasmas	en
dc.subject.other	Laser spectroscopy	en
dc.subject.other	Lasers	en
dc.subject.other	Optical properties	en
dc.subject.other	Pathology	en
dc.subject.other	Quantum electronics	en
dc.subject.other	Skin	en
dc.subject.other	Spectroscopic analysis	en
dc.subject.other	Spectrum analysis	en
dc.subject.other	Tomography	en
dc.subject.other	Tumors	en
dc.subject.other	Autofluorescence	en
dc.subject.other	Basal cell carcinomas	en
dc.subject.other	Bio-photonics	en
dc.subject.other	Excitation sources	en
dc.subject.other	Human datum	en
dc.subject.other	Human disease	en
dc.subject.other	Human skins	en
dc.subject.other	Human tissues	en
dc.subject.other	Laser-based techniques	en
dc.subject.other	Laser-induced fluorescence spectroscopies	en
dc.subject.other	Light-scattering spectrum	en
dc.subject.other	Mathematical simulations	en
dc.subject.other	Medical analysis	en
dc.subject.other	Monte carlo	en
dc.subject.other	Multi-layered	en
dc.subject.other	Nitrogen lasers	en
dc.subject.other	Non-invasive	en
dc.subject.other	Normal skins	en
dc.subject.other	Ocular disease	en
dc.subject.other	Ocular tissues	en
dc.subject.other	Optical-coherence tomographies	en
dc.subject.other	Quantitative analysis	en
dc.subject.other	Spectroscopy measurements	en
dc.subject.other	Theoretical results	en
dc.subject.other	Tissue pathologies	en
dc.subject.other	Tissue properties	en
dc.subject.other	Tissue samples	en
dc.subject.other	Ultra violet excitations	en
dc.subject.other	Laser excitation	en
dc.title	Biophotonics in diagnosis and modeling of tissue pathologies	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1117/12.822517	en
heal.identifier.secondary	http://dx.doi.org/10.1117/12.822517	en
heal.identifier.secondary	702715	en
heal.publicationDate	2008	en
heal.abstract	Biophotonics techniques are applied to several fields in medicine and biology. The laser based techniques, such as the laser induced fluorescence (LIF) spectroscopy and the optical coherence tomography (OCT), are of particular importance in dermatology, where the laser radiation could be directly applied to the tissue target (e.g. skin). In addition, OCT resolves architectural tissue properties that might be useful as tumour discrimination parameters for skin as well as for ocular non-invasive visualization. Skin and ocular tissues are complex multilayered and inhomogeneous organs with spatially varying optical properties. This fact complicates the quantitative analysis of the fluorescence and/or light scattering spectra, even from the same tissue sample. To overcome this problem, mathematical simulation is applied for the investigation of the human tissue optical properties, in the visible/infrared range of the spectrum, resulting in a better discrimination of several tissue pathologies. In this work, we present i) a general view on biophotonics applications in diagnosis of human diseases, ii) some specific results on laser spectroscopy techniques, as LIF measurements, applied in arterial and skin pathologies and iii) some experimental and theoretical results on ocular OCT measurements. Regarding the LIF spectroscopy, we examined the autofluorescence properties of several human skin samples, excised from humans undergoing biopsy examination. A nitrogen laser was used as an excitation source, emitting at 337 nm (ultraviolet excitation). Histopathology examination of the samples was also performed, after the laser spectroscopy measurements and the results from the spectroscopic and medical analysis were compared, to differentiate malignancies, e.g. basal cell carcinoma tissue (BCC), from normal skin tissue. Regarding the OCT technique, we correlated human data, obtained from patients undergoing OCT examination, with Monte Carlo simulated cornea and retina tissues for diagnosis of ocular diseases. © 2008 SPIE.	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.doi	10.1117/12.822517	en
dc.identifier.volume	7027	en