A coupled radiative transfer and diffusion approximation model for the solution of the forward problem and the a-priori fluorophore distribution estimation in fluorescence imaging

Gorpas, D; Yova, D; Politopoulos, K

dc.contributor.author	Gorpas, D	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Politopoulos, K	en
dc.date.accessioned	2014-03-01T02:51:54Z
dc.date.available	2014-03-01T02:51:54Z
dc.date.issued	2009	en
dc.identifier.issn	0277786X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/35740
dc.subject	Diffusion approximation	en
dc.subject	Finite elements	en
dc.subject	Fluorescence molecular imaging	en
dc.subject	Forward problem	en
dc.subject	Radiative transfer equation	en
dc.subject	Super-ellipsoid models	en
dc.subject.other	Diffusion approximation	en
dc.subject.other	Finite elements	en
dc.subject.other	Fluorescence molecular imaging	en
dc.subject.other	Forward problem	en
dc.subject.other	Radiative transfer equation	en
dc.subject.other	Super-ellipsoid models	en
dc.subject.other	Diffusion	en
dc.subject.other	Heat radiation	en
dc.subject.other	Image processing	en
dc.subject.other	Inverse problems	en
dc.subject.other	Radiative transfer	en
dc.subject.other	Tumors	en
dc.subject.other	Fluorophores	en
dc.title	A coupled radiative transfer and diffusion approximation model for the solution of the forward problem and the a-priori fluorophore distribution estimation in fluorescence imaging	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1117/12.808116	en
heal.identifier.secondary	http://dx.doi.org/10.1117/12.808116	en
heal.identifier.secondary	71710A	en
heal.publicationDate	2009	en
heal.abstract	Although fluorescence imaging has been applied in tumour diagnosis from the early 90s, just the last few years it has met an increasing scientific interest due to the advances in the biophotonics field and the combined technological progress of the acquisition and computational systems. In addition there are expectations that fluorescence imaging will be further developed and applied in deep tumour diagnosis in the years to come. However, this evolving field of imaging sciences has still to encounter important challenges. Among them is the expression of an accurate forward model for the solution of the reconstruction problem. The scope of this work is to introduce a three dimensional coupled radiative transfer and diffusion approximation model, applicable on the fluorescence imaging. Furthermore, the solver incorporates the superellipsoid models and sophisticated image processing algorithms to additionally provide a-priori estimation about the fluorophores distribution, information that is very important for the solution of the inverse problem. Simulation experiments have proven that the proposed methodology preserves the accuracy levels of the radiative transfer equation and the time efficacy of the diffusion approximation, while in the same time shows extended success on the registration between acquired and simulated images. © 2009 SPIE.	en
heal.journalName	Proceedings of SPIE - The International Society for Optical Engineering	en
dc.identifier.doi	10.1117/12.808116	en
dc.identifier.volume	7171	en