The role of synaptic parameters in a parkinsonian population level model of the basal ganglia

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dc.contributor.author Tsirogiannis, GL en
dc.contributor.author Tagaris, GA en
dc.contributor.author Sakas, D en
dc.contributor.author Nikita, KS en
dc.date.accessioned 2014-03-01T02:52:12Z
dc.date.available 2014-03-01T02:52:12Z
dc.date.issued 2009 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/35865
dc.subject Basal ganglia en
dc.subject Beta band peak en
dc.subject Dopamine modulation en
dc.subject Local field potentials en
dc.subject Parkinson's disease en
dc.subject Population level models en
dc.subject.other Basal ganglia en
dc.subject.other Beta band peak en
dc.subject.other Dopamine modulation en
dc.subject.other Local field potentials en
dc.subject.other Parkinson's disease en
dc.subject.other Population level models en
dc.subject.other Brain en
dc.subject.other Independent component analysis en
dc.subject.other Power spectral density en
dc.subject.other Dispensers en
dc.title The role of synaptic parameters in a parkinsonian population level model of the basal ganglia en
heal.type conferenceItem en
heal.identifier.primary 10.1109/NER.2009.5109363 en
heal.identifier.secondary http://dx.doi.org/10.1109/NER.2009.5109363 en
heal.identifier.secondary 5109363 en
heal.publicationDate 2009 en
heal.abstract A persistent hallmark of Parkinson's disease is a beta band peak in the power spectral density function of the Local Field Potential (LFP) signals, derived from basal ganglia's subthalamic nucleus microelectrode recordings. The peak's role in parkinsonian pathophysiology is thought to be central. A new proposed population level model of the basal ganglia generates parkinsonian LFPs by expressing a beta band peak. For that to take place, the neurophysiological parameters that suffer pathogenic modification are shown to be both the amplitude and the duration of the post-synaptic potentials. ©2009 IEEE. en
heal.journalName 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 en
dc.identifier.doi 10.1109/NER.2009.5109363 en
dc.identifier.spage 581 en
dc.identifier.epage 584 en

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