Evaluation of capacitive surface stress biosensors

Tsouti, V; Boutopoulos, C; Ioannou, M; Goustouridis, D; Kafetzopoulos, D; Zergioti, I; Tsoukalas, D; Normand, P; Chatzandroulis, S

dc.contributor.author	Tsouti, V	en
dc.contributor.author	Boutopoulos, C	en
dc.contributor.author	Ioannou, M	en
dc.contributor.author	Goustouridis, D	en
dc.contributor.author	Kafetzopoulos, D	en
dc.contributor.author	Zergioti, I	en
dc.contributor.author	Tsoukalas, D	en
dc.contributor.author	Normand, P	en
dc.contributor.author	Chatzandroulis, S	en
dc.date.accessioned	2014-03-01T02:53:38Z
dc.date.available	2014-03-01T02:53:38Z
dc.date.issued	2012	en
dc.identifier.issn	01679317	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/36457
dc.subject	Biosensor	en
dc.subject	Capacitive biosensor	en
dc.subject	DNA	en
dc.subject	Thin membrane	en
dc.subject.other	Biological interactions	en
dc.subject.other	Biological targets	en
dc.subject.other	Biosensing elements	en
dc.subject.other	Biosensor arrays	en
dc.subject.other	Capacitive biosensors	en
dc.subject.other	Capacitive type	en
dc.subject.other	matrix	en
dc.subject.other	Sample concentration	en
dc.subject.other	Sensing elements	en
dc.subject.other	Surface stress	en
dc.subject.other	Thin membrane	en
dc.subject.other	DNA	en
dc.subject.other	Oligonucleotides	en
dc.subject.other	Polymerase chain reaction	en
dc.subject.other	Surface properties	en
dc.subject.other	Biosensors	en
dc.title	Evaluation of capacitive surface stress biosensors	en
heal.type	conferenceItem	en
heal.identifier.primary	10.1016/j.mee.2011.05.027	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.mee.2011.05.027	en
heal.publicationDate	2012	en
heal.abstract	The evaluation of a capacitive type biosensor array, consisting of a total of 256 biosensing elements, in the detection of single oligonucleotide mutations is presented. The biosensor takes advantage of surface stress changes during biological interactions and is able to translate them into a capacitive signal. The array is organized in a 16 × 16 matrix of distinct biosensing elements thus allowing for the concurrent sensing of multiple biological targets. In this work the sensing elements of the array are spotted with three different oligonucleotides (CD8, CD17 and CD19) and their hybridization is detected using 36 nM PCR. Moreover tests with CD19 revealed the ability of the biosensor to detect the hybridization of the oligo with sample concentrations of 36, 18 and 9 nM. © 2011 Elsevier B.V. All rights reserved.	en
heal.journalName	Microelectronic Engineering	en
dc.identifier.doi	10.1016/j.mee.2011.05.027	en
dc.identifier.volume	90	en
dc.identifier.spage	37	en
dc.identifier.epage	39	en