Design of a low power target for direct cyclotron production of 99mTc

Λιβανού, Αναστασία; Livanou, Anastasia

dc.contributor.author	Λιβανού, Αναστασία	el
dc.contributor.author	Livanou, Anastasia	en
dc.date.accessioned	2017-03-08T07:56:43Z
dc.date.available	2017-03-08T07:56:43Z
dc.date.issued	2017-03-08
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/44548
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.13303
dc.rights	Default License
dc.subject	optimized target disc ,radionuclides, Nuclear medicine,cyclotron	el
dc.title	Design of a low power target for direct cyclotron production of 99mTc	en
dc.title	Σχεδίαση ενός στόχου χαμηλής ισχύος για την απευθείας παραγωγή σε κυκλοτρό 99mTc	el
heal.type	bachelorThesis
heal.classification	Nuclear Medicine	en
heal.language	el
heal.language	en
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2015-10-15
heal.abstract	The purpose of this thesis is the design and construction of a target support capable to host a variety of materials (pellets, metal foils, etc.) for cyclotron production of 99mTc in quantities sufficient for local clinical use without requiring complicated and expensive techniques of target preparation. The need to conduct this thesis emerged due to shortages of reactor produced 99Mo-99mTc leading to the alternative direct production of 99mTc via the 100Mo (p,2n)99mTc reaction in the cyclotron. In this thesis, which was conducted at the Medical Physics Unit of the Bologna Hospital ‘’ S. Orsola-Malpighi University Hospital ‘’ I designed an optimized target disc for the GE PETrace cyclotron by the use of Software Solidworks. In particular, Solidworks was chosen because it’s ideal to create a full solid model in a simulated environment for both design and analysis. The new target system was made of two parts: a support (or backing), aimed to contain the effective target material and a front piece that allows to keep the target material in position. Copper was selected as the material of choice, due to its availability, relatively low cost, excellent thermal conductivity and ease of machining For the design verification and validation, a testing plan was created which incorporated specification of the applicable operational parameters as well as the acceptable performance criteria. By reviewing the usage of a very similar existing technological solution, it has been concluded that practically no structural stress is applied to any of the parts of the apparatus, either during the initial fitting, or during the radiation bombardment. Thermal simulations were performed using Ansys Software and the results showed that the temperatures even near the target face, the most exposed to heat stress, remained well below the material melting temperature (copper melting temperature-1082,3 oC) which certainly ensured the physical integrity of the target disc. Due to time limitations, only a limited testing of the first prototype of target support was possible. The enriched target material used was a series of 5 100Mo sheets.The target was irradiated for 90 minutes at a current of 20 μA. A final solution of purified 99mTc pertechnetate was obtained, with an activity of 686 MBq at 4h.A sample of 259 MBq was taken from the final solution and injected into a typical phantom for evaluation of the performance in SPECT imaging and a tomographic acquisition was performed using a Siemens E.cam dual head gamma camera, fitted with Low Energy High resolution collimators. Tomographic acquisition was also performed. In conclusion, this work successfully represented a first step in a new direction of investigation in the design of targetry for cyclotron production of 99mTc.	en
heal.sponsor	πρόγραμμα Erasmus	el
heal.advisorName	Αναγνωστάκης, Μάριος	el
heal.committeeMemberName	Ρούνη, Παναγιώτα	el
heal.committeeMemberName	Χίνης, Ευάγγελος	el
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Μηχανολόγων Μηχανικών. Τομέας Πυρηνικής Τεχνολογίας	el
heal.academicPublisherID	ntua
heal.numberOfPages	70 σ.	el
heal.fullTextAvailability	true