Process design and optimisation for continuous pharmaceutical manufacturing of atropine and diazepam

Μύτης, Νικόλαος; Mytis, Nikolaos

dc.contributor.author	Μύτης, Νικόλαος	el
dc.contributor.author	Mytis, Nikolaos	en
dc.date.accessioned	2018-10-30T11:31:41Z
dc.date.available	2018-10-30T11:31:41Z
dc.date.issued	2018-10-30
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/47862
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.16032
dc.rights	Αναφορά Δημιουργού 3.0 Ελλάδα	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/gr/	*
dc.subject	Pharmaceutical	en
dc.subject	Optimisation	en
dc.subject	Models	en
dc.subject	Continuous	en
dc.subject	Process	en
dc.subject	Αριστοποίηση	el
dc.subject	Φάρμακα	el
dc.subject	Διεργασίες	el
dc.subject	Μοντέλα	el
dc.subject	Συνεχής	el
dc.title	Process design and optimisation for continuous pharmaceutical manufacturing of atropine and diazepam	en
heal.type	bachelorThesis
heal.classification	Optimisation of chemical processes	en
heal.classification	Pharmaceutical industry--Europe	en
heal.classification	Process engineering	en
heal.classification	Chemical processes--Mathematical models	en
heal.classification	Χημικοί αντιδραστήρες	el
heal.classification	Χημική θερμοδυναμική	el
heal.classification	Microreactors	en
heal.classificationURI	http://data.seab.gr/concepts/1a2ad4bd48d1800dc264d02b00c079f932a28633
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2010105982
heal.classificationURI	http://zbw.eu/stw/descriptor/15677-1
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2009118798
heal.classificationURI	http://data.seab.gr/concepts/2cdb127927b75ed7069e51024e2b09031996ebe9
heal.classificationURI	http://data.seab.gr/concepts/12f978f53da9dfd6e96febfecdddcd4833f20027
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00004949
heal.language	en
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2018-07-07
heal.abstract	Continuous Pharmaceutical Manufacturing (CPM) is a modern industrial paradigm for the production of active pharmaceutical ingredients, providing significant benefits over its batch counterpart, including increased efficiency, cost savings, quality control and safety. The transformation of the pharmaceutical industry requires detailed technoeconomic evaluations. The continuous flow synthesis of atropine and diazepam, two popular drugs with high global sales, has been recently demonstrated. In this work, a CPM flowsheet model is established and optimised for each API, featuring novel kinetic expressions fitted to data, reactor design, separation thermodynamics, mass transfer, liquid-liquid extraction design and costing. Several design variables are calculated by minimising the total cost for a plant with capacity of 100 kg API per annum and a lifetime of 20 years. Different solvents, temperatures and solvent recovery percentage cases are considered. The results are then analysed in order to demonstrate the feasibility of the plants. It was found that the continuous production of atropine is efficient, achieving low operational cost, wastage and E-factors, and yielding high purity. The continuous production of diazepam is not efficient, based on continuous flow chemistry used in this work, as it results in excessive solvent use. There are however promising alternative methods for its continuous production.	en
heal.sponsor	Erasmus+	en
heal.advisorName	Μπουντουβής, Ανδρέας	el
heal.committeeMemberName	Μπουντουβής, Ανδρέας	el
heal.committeeMemberName	Γερογιώργης, Δημήτριος	el
heal.committeeMemberName	Αργυρούσης, Χρήστος	el
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών. Τομέας Ανάλυσης, Σχεδιασμού και Ανάπτυξης Διεργασιών και Συστημάτων (ΙΙ)	el
heal.academicPublisherID	ntua
heal.numberOfPages	45 σ.
heal.fullTextAvailability	true