dc.contributor.author | Papamichael, Iliana![]() |
en |
dc.contributor.author | Παπαμιχαήλ, Ηλιάνα![]() |
el |
dc.date.accessioned | 2020-02-17T09:52:57Z | |
dc.date.available | 2020-02-17T09:52:57Z | |
dc.identifier.uri | https://dspace.lib.ntua.gr/xmlui/handle/123456789/49789 | |
dc.rights | Αναφορά Δημιουργού-Όχι Παράγωγα Έργα 3.0 Ελλάδα | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nd/3.0/gr/ | * |
dc.subject | Χημική μηχανική | el |
dc.subject | Τεχνική και επιστήμη των υλικών | el |
dc.subject | Μοριακή δομή των οστών | el |
dc.subject | Επίδραση ασθενειών σε οστίτη ιστό | el |
dc.subject | Φασματοσκοπία υπέρυθρου | el |
dc.subject | Chemical engineering | en |
dc.subject | Structure and states of matter | en |
dc.subject | Molecular structure of bones | en |
dc.subject | Effect of various diseases on bone tissue | en |
dc.subject | Infrared spectroscopy | en |
dc.title | Διερεύνηση της επίδρασης ασθενειών στη μοριακή δομή των οστών με την εφαρμογή της υπέρυθρης φασματοσκοπίας | el |
heal.type | bachelorThesis | |
heal.classification | Επιστήμη και τεχνική των υλικών | el |
heal.language | el | |
heal.access | free | |
heal.recordProvider | ntua | el |
heal.publicationDate | 2019-09-25 | |
heal.abstract | In the present study, Attenuated Total Reflectance- Fourier Transform Infrared Spectroscopy (ATR-FTIR) in combination with Scanning Electron Microscope (SEM) were used in order to study the influence of the diseases on the molecular structure of bones. For this purpose, samples were obtained from patients undergoing osteoarthritic surgery or surgery due to a fracture. Based on the clinical history of the patients, the conditions that were observed were osteoporosis, Type II Diabetes, Metastatic Colorectal Cancer and epilepsy. From the analysis of the molecular structure and damage of the samples at the region 4000-400 cm-1, many differences regarding the intensity and frequency of the peeks were observed in comparison with the healthy bone sample. These variations were due to the changes in the structure of collagen proteins and the hydroxyapatite of bones. Furthermore, observations were made concerning the cancerous samples, where there was an extreme influence of free radicals and oxidative stress to the bone structure compared to the healthy bone sample. This confirms the suggestion that the free radicals are involved in hyperoxidation of lipids in a pathway of the disease development. Additionally, the SEM images confirmed the results obtained by ATR-FTIR, revealing areas of low bone density, transition metals involvement in oxidative stress and increased amyloid protein concentration in the presence of cancer. As a conclusion to the series of these experiments, Infrared spectroscopy can give fast and accurate results in regards to the existence, state and effect of a medical condition. | en |
heal.advisorName | Καραγιάννη, Χάιδω-Στεφανία | |
heal.committeeMemberName | Τσιβιλής, Σωτήριος | |
heal.committeeMemberName | Κορδάτος, Κωνσταντίνος | |
heal.academicPublisher | Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών. Τομέας Επιστήμης και Τεχνικής των Υλικών (ΙΙΙ) | el |
heal.academicPublisherID | ntua | |
heal.numberOfPages | 93 σ. | |
heal.fullTextAvailability | false |
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