Διερεύνηση της επίδρασης ασθενειών στη μοριακή δομή των οστών με την εφαρμογή της υπέρυθρης φασματοσκοπίας

Papamichael, Iliana; Παπαμιχαήλ, Ηλιάνα

dc.contributor.author	Papamichael, Iliana	en
dc.contributor.author	Παπαμιχαήλ, Ηλιάνα	el
dc.date.accessioned	2020-02-17T09:52:57Z
dc.date.available	2020-02-17T09:52:57Z
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/49789
dc.rights	Αναφορά Δημιουργού-Όχι Παράγωγα Έργα 3.0 Ελλάδα	*
dc.rights.uri	http://creativecommons.org/licenses/by-nd/3.0/gr/	*
dc.subject	Χημική μηχανική	el
dc.subject	Τεχνική και επιστήμη των υλικών	el
dc.subject	Μοριακή δομή των οστών	el
dc.subject	Επίδραση ασθενειών σε οστίτη ιστό	el
dc.subject	Φασματοσκοπία υπέρυθρου	el
dc.subject	Chemical engineering	en
dc.subject	Structure and states of matter	en
dc.subject	Molecular structure of bones	en
dc.subject	Effect of various diseases on bone tissue	en
dc.subject	Infrared spectroscopy	en
dc.title	Διερεύνηση της επίδρασης ασθενειών στη μοριακή δομή των οστών με την εφαρμογή της υπέρυθρης φασματοσκοπίας	el
heal.type	bachelorThesis
heal.classification	Επιστήμη και τεχνική των υλικών	el
heal.language	el
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2019-09-25
heal.abstract	In the present study, Attenuated Total Reflectance- Fourier Transform Infrared Spectroscopy (ATR-FTIR) in combination with Scanning Electron Microscope (SEM) were used in order to study the influence of the diseases on the molecular structure of bones. For this purpose, samples were obtained from patients undergoing osteoarthritic surgery or surgery due to a fracture. Based on the clinical history of the patients, the conditions that were observed were osteoporosis, Type II Diabetes, Metastatic Colorectal Cancer and epilepsy. From the analysis of the molecular structure and damage of the samples at the region 4000-400 cm-1, many differences regarding the intensity and frequency of the peeks were observed in comparison with the healthy bone sample. These variations were due to the changes in the structure of collagen proteins and the hydroxyapatite of bones. Furthermore, observations were made concerning the cancerous samples, where there was an extreme influence of free radicals and oxidative stress to the bone structure compared to the healthy bone sample. This confirms the suggestion that the free radicals are involved in hyperoxidation of lipids in a pathway of the disease development. Additionally, the SEM images confirmed the results obtained by ATR-FTIR, revealing areas of low bone density, transition metals involvement in oxidative stress and increased amyloid protein concentration in the presence of cancer. As a conclusion to the series of these experiments, Infrared spectroscopy can give fast and accurate results in regards to the existence, state and effect of a medical condition.	en
heal.advisorName	Καραγιάννη, Χάιδω-Στεφανία
heal.committeeMemberName	Τσιβιλής, Σωτήριος
heal.committeeMemberName	Κορδάτος, Κωνσταντίνος
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Χημικών Μηχανικών. Τομέας Επιστήμης και Τεχνικής των Υλικών (ΙΙΙ)	el
heal.academicPublisherID	ntua
heal.numberOfPages	93 σ.
heal.fullTextAvailability	false