Η δυναμική της φυσαλίδας σπηλαίωσης σε μαλακούς ιστούς υπό διέγερση διπλής συχνότητας

Παπαγεωργίου, Σταυρούλα; Papageorgiou, Stavroula

dc.contributor.author	Παπαγεωργίου, Σταυρούλα	el
dc.contributor.author	Papageorgiou, Stavroula	en
dc.date.accessioned	2022-02-17T06:55:22Z
dc.date.available	2022-02-17T06:55:22Z
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/54741
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.22439
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση 3.0 Ελλάδα	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc/3.0/gr/	*
dc.subject	Μικροφυσαλίδες	el
dc.subject	Σπηλαίωση	el
dc.subject	Υψηλής έντασης	el
dc.subject	Υπέρηχοι	el
dc.subject	Μαλακοι ιστοι	el
dc.subject	Microbubbles	en
dc.subject	HIFU	en
dc.subject	Ultrasounds	en
dc.subject	Soft tissues	en
dc.subject	Ultrasounds	en
dc.title	Η δυναμική της φυσαλίδας σπηλαίωσης σε μαλακούς ιστούς υπό διέγερση διπλής συχνότητας	el
dc.title	The dynamics of bubble cavitation in soft tissues under dual-frequency HIFU stimulation	en
heal.type	bachelorThesis
heal.classification	Μηχανική ρευστών	el
heal.language	el
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2021-10-04
heal.abstract	Bubbles appear in many technological and industrial applications, in the fields of medicine, pharmacology, materials science and the chemical industry. In medicine, microbubbles are used as contrast agents in combination with ultrasound waves, as they amplify the signal, improving image quality. They are also applied to new therapeutic techniques aimed at eliminating clots or removing tumors, as they can be selectively directed to specific targets. These important applications underscore the importance of knowing the physical behavior of bubbles under ultrasound waves. Despite the potential impact this technology could have on the clinic, there are currently concerns about its effectiveness, uniformity and safety. These challenges are ultimately due to the limited ability to control the dynamics of microbubbles during ultrasound exposure. The present Thesis provides some insight information on the physics of isolated bubbles placed in an infinite medium. The corresponding flow equations are solved numerically, providing predictions of the pressures and temperatures developing inside collapsing bubbles at conditions considering the physical properties of various human tissues. The simulation results suggest that the same amplitudes of individual components, and frequency difference are beneficial for enhancing the bubble cavitation.The effect of the dualfrequency excitation on the inertial cavitation threshold was studied to optimize the outcome. Especially in the tissues, heart and brain, dual frequency and especially 3. 1+3. 5 MHz brought about a significant increase in temperature and pressure which is desirable in therapeutic applications of microbubbles. Overall, this work may provide a theoretical model for further investigation of dualfrequency excitation and its applications for a better outcome.	en
heal.advisorName	Καρέλλας, Σωτήριος	el
heal.committeeMemberName	Καρέλλας, Σωτήριος	el
heal.committeeMemberName	Γκαβαισες, Μανώλης	el
heal.academicPublisher	Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Μηχανολόγων Μηχανικών. Τομέας Θερμότητας	el
heal.academicPublisherID	ntua
heal.numberOfPages	105 σ.	el
heal.fullTextAvailability	false