Atomic Force Microscopy Imaging of Elastin Nanofibers
Self-Assembly

Sambani, Kyriaki

dc.contributor.author	Sambani, Kyriaki
dc.date.accessioned	2024-07-24T18:16:40Z
dc.date.available	2024-07-24T18:16:40Z
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/59959
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.27655
dc.rights	Default License
dc.subject	Elastin nanofibrils	en
dc.subject	Atomic force microscopy (AFM)	en
dc.subject	Nanoscale imaging	en
dc.subject	Elastin self-assembly	en
dc.subject	Nanobiomaterials	en
dc.title	Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly	en
heal.type	journalArticle
heal.classification	Biomaterials	el
heal.contributorName	Sambani, Kyriaki
heal.contributorName	Kontomaris, Stylianos Vasileios
heal.contributorName	Yova, Dido
heal.language	en
heal.access	free
heal.recordProvider	ntua	el
heal.publicationDate	2023-06-11
heal.bibliographicCitation	Sambani, K.; Kontomaris, S.V.; Yova, D. Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly. Materials 2023, 16, 4313.	en
heal.abstract	Elastin is an extracellular matrix protein, providing elasticity to the organs, such as skin, blood vessels, lungs and elastic ligaments, presenting self-assembling ability to form elastic fibers. The elastin protein, as a component of elastin fibers, is one of the major proteins found in connective tissue and is responsible for the elasticity of tissues. It provides resilience to the human body, assembled as a continuous mesh of fibers that require to be deformed repetitively and reversibly. Thus, it is of great importance to investigate the development of the nanostructural surface of elastin-based biomaterials. The purpose of this research was to image the self-assembling process of elastin fiber structure under different experimental parameters such as suspension medium, elastin concentration, temperature of stock suspension and time interval after the preparation of the stock suspension. atomic force microscopy (AFM) was applied in order to investigate how different experimental parameters affected fiber development and morphology. The results demonstrated that through altering a number of experimental parameters, it was possible to affect the self-assembly procedure of elastin fibers from nanofibers and the formation of elastin nanostructured mesh consisting of naturally occurring fibers. Further clarification of the contribution of different parameters on fibril formation will enable the design and control of elastin-based nanobiomaterials with predetermined characteristics.	en
heal.publisher	Dr. Anya Osborn	en
heal.journalName	Materials	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false
dc.identifier.doi	https://doi.org/10.3390/ma16124313	el