Process design for the extraction of bioactive compounds from several mediterranean medicinal plants

Laina, Konstantina Theodora; Eleni, Panagiota Maria; Tsitseli, Konstantina; Krokida, Magdalini

dc.contributor.author	Laina, Konstantina Theodora
dc.contributor.author	Eleni, Panagiota Maria
dc.contributor.author	Tsitseli, Konstantina
dc.contributor.author	Krokida, Magdalini
dc.date.accessioned	2024-10-21T09:56:17Z
dc.identifier.issn	22839216	el
dc.identifier.other	https://doi.org/10.3303/CET2186222	el
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/60303
dc.identifier.uri	http://dx.doi.org/10.26240/heal.ntua.27999
dc.rights	Default License
dc.subject	Bioactive Compounds	en
dc.subject	Extraction Technology	en
dc.subject	Medicinal Plants	en
dc.subject	Ultrasound and Microwave Assisted Extraction	en
dc.title	Process design for the extraction of bioactive compounds from several mediterranean medicinal plants	en
heal.type	journalArticle
heal.classification	Chemical Engineering	en
heal.classification	Extraction Technology	en
heal.classification	Process Engineering	en
heal.classification	Green Chemistry	en
heal.dateAvailable	2025-10-20T21:00:00Z
heal.language	en
heal.access	embargo
heal.recordProvider	ntua	el
heal.publicationDate	2021-06-15
heal.bibliographicCitation	Laina K.M., Eleni P.N., Tsitseli K.G., Krokida M.K., 2021, Process Design for the Extraction of Bioactive Compounds from Several Mediterranean Medicinal Plants, Chemical Engineering Transactions, 86, 1327-1332.	en
heal.abstract	The objective of this study was the optimization of the extraction process of several medicinal plants of the Mediterranean flora, and their extracts' further evaluation regarding their potential biological activity. This work aimed to design and optimize the extraction method for recovering the targeted compounds from rosemary (Rosmarinus officinalis), St. John's wort (Hypericum perforatum) and chamomile (Matricaria recutita) towards the extraction yield and quality of the extracts. Raw materials were collected, dried, and ground in desired particle sizes (200, 500, 1000 μm). Ethanol was used as solvent; and extraction was performed using conventional extraction methods (Soxhlet), as well as novel extraction techniques (Ultrasound Assisted Extraction (UAE), Microwave Assisted Extraction (MAE) and their combination (UAE-MAE)). The optimized parameters were Ultrasound and Microwave intensity, and extraction time. All extracts were evaluated towards their total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity. TPC was determined by Folin-Ciocalteu method, while the antioxidant activity was estimated with the DPPH assay. Optimum particle size was 500 μm for rosemary, and 1000 μm for both St. John's wort and chamomile. In general, the increase of extraction time leads to increase of efficiency. However, the extraction time is not an independent variable, since the ultrasound and microwave intensities affect the yield. In specific, the increment of intensity in both techniques, as well as their combination, increases the efficiency of the extraction and reduces the time. Moreover, it was observed that after a certain intensity value the yield remains constant or slightly decreases, due to degradation phenomena. Thus, the optimum ultrasound intensity for rosemary and chamomile was 450 W, while for St. John's wort was 700 W. Regarding microwave extraction parameters, for all tested plants the value of 200 W was selected as optimum, except for St. John's wort (200 W). The optimum set of values were also selected for UAE-MAE. Results also indicate that the extracts were rich in phenolic compounds, possessing also a remarkable antioxidant activity in all the organic solvent systems tested.	en
heal.publisher	Italian Association of Chemical Engineering - AIDIC	en
heal.journalName	Chemical Engineering Transactions	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false
dc.identifier.doi	10.3303/CET2186222	el