Raman spectroscopy of uncomplexed valinomycin. 2. Nonpolar and polar solution

Rothschild, KJ; Asher, IM; Stanley, HE; Anastassakis, E

dc.contributor.author	Rothschild, KJ	en
dc.contributor.author	Asher, IM	en
dc.contributor.author	Stanley, HE	en
dc.contributor.author	Anastassakis, E	en
dc.date.accessioned	2014-03-01T01:05:38Z
dc.date.available	2014-03-01T01:05:38Z
dc.date.issued	1977	en
dc.identifier.issn	0002-7863	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/8915
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-0017372960&partnerID=40&md5=cfd8960100656057f0f26c15b7c2e39b	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.other	valinomycin	en
dc.subject.other	drug analysis	en
dc.subject.other	drug structure	en
dc.subject.other	in vitro study	en
dc.subject.other	raman spectrometry	en
dc.subject.other	theoretical study	en
dc.subject.other	Protein Conformation	en
dc.subject.other	Solutions	en
dc.subject.other	Solvents	en
dc.subject.other	Spectrum Analysis, Raman	en
dc.subject.other	Support, U.S. Gov't, P.H.S.	en
dc.subject.other	Valinomycin	en
dc.title	Raman spectroscopy of uncomplexed valinomycin. 2. Nonpolar and polar solution	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1977	en
heal.abstract	The molecular conformations of uncomplexed valinomycin in CCl4, CS2, CH2Cl2, CHCl3, CH3OH, C2H5OH, C3H7Cl, p-dioxane (C4H8O2), and dioxane/D2O have been studied using laser Raman spectroscopy. The stretching frequencies of the ester and amide carbonyl groups are found to be affected by both the polarity of the solvent and its ability to form hydrogen bonds. Results in nonpolar solvents are consistent with the presence of hydrogen bonding ester carbonyl groups, reopening the question of whether the conformation found in valinomycin recrystallized from n-octane can exist in nonpolar solution. In polar solvents, a conformation is detected that contains fewer hydrogen bonds. As the dielectric constant of the solvent increases, the stretching frequency of the amide carbonyl groups increases (perhaps reflecting a reduction of intramolecular hydrogen bonding), while the stretching frequency of the ester carbonyl groups decreases.	en
heal.publisher	AMER CHEMICAL SOC	en
heal.journalName	Journal of the American Chemical Society	en
dc.identifier.isi	ISI:A1977CZ99900003	en
dc.identifier.volume	99	en
dc.identifier.issue	7	en
dc.identifier.spage	2032	en
dc.identifier.epage	2039	en