NMR and FT-IR conformational studies of 8-substituted guanine nucleosides and nucleotides and their metal adducts and cancer

Polissiou, M; Theophanides, T

dc.contributor.author	Polissiou, M	en
dc.contributor.author	Theophanides, T	en
dc.date.accessioned	2014-03-01T01:06:55Z
dc.date.available	2014-03-01T01:06:55Z
dc.date.issued	1987	en
dc.identifier.issn	0020-1693	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/9678
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-4243688621&partnerID=40&md5=2a3615ba5876a9d16430af10ae7b5f4d	en
dc.subject.classification	Chemistry, Inorganic & Nuclear	en
dc.title	NMR and FT-IR conformational studies of 8-substituted guanine nucleosides and nucleotides and their metal adducts and cancer	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	1987	en
heal.abstract	NMR and FT-IR Studies of the conformational changes of guanosine and guanosine-5′-monophosphate upon substitution of the H8 of guanine by a heavy, large atom, such as bromine, are presented. The conformational forms, syn, anti, C2′-endo and C3′-endo and gg, gt and tg rotamers of the above molecules are compared to those of their metal (Mg2+ and Pt2+) adducts, where the metal is fixed to the N7 nitrogen atom of guanine. The antitumor activity of cisplatin is discussed with relation to the conformational form and the effect of cisplatin is compared to the effects of the Mg2+ ion and carcinogens. © 1987.	en
heal.publisher	ELSEVIER SCIENCE SA LAUSANNE	en
heal.journalName	Inorganica Chimica Acta	en
dc.identifier.isi	ISI:A1987K077000013	en
dc.identifier.volume	137	en
dc.identifier.issue	3	en
dc.identifier.spage	195	en
dc.identifier.epage	201	en