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NMR and FT-IR conformational studies of 8-substituted guanine nucleosides and nucleotides and their metal adducts and cancer

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dc.contributor.author Polissiou, M en
dc.contributor.author Theophanides, T en
dc.date.accessioned 2014-03-01T01:06:55Z
dc.date.available 2014-03-01T01:06:55Z
dc.date.issued 1987 en
dc.identifier.issn 0020-1693 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/9678
dc.relation.uri http://www.scopus.com/inward/record.url?eid=2-s2.0-4243688621&partnerID=40&md5=2a3615ba5876a9d16430af10ae7b5f4d en
dc.subject.classification Chemistry, Inorganic & Nuclear en
dc.title NMR and FT-IR conformational studies of 8-substituted guanine nucleosides and nucleotides and their metal adducts and cancer en
heal.type journalArticle en
heal.language English en
heal.publicationDate 1987 en
heal.abstract NMR and FT-IR Studies of the conformational changes of guanosine and guanosine-5′-monophosphate upon substitution of the H8 of guanine by a heavy, large atom, such as bromine, are presented. The conformational forms, syn, anti, C2′-endo and C3′-endo and gg, gt and tg rotamers of the above molecules are compared to those of their metal (Mg2+ and Pt2+) adducts, where the metal is fixed to the N7 nitrogen atom of guanine. The antitumor activity of cisplatin is discussed with relation to the conformational form and the effect of cisplatin is compared to the effects of the Mg2+ ion and carcinogens. © 1987. en
heal.publisher ELSEVIER SCIENCE SA LAUSANNE en
heal.journalName Inorganica Chimica Acta en
dc.identifier.isi ISI:A1987K077000013 en
dc.identifier.volume 137 en
dc.identifier.issue 3 en
dc.identifier.spage 195 en
dc.identifier.epage 201 en


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