Breast diseases: Histopathological study of six hundred forty-two cases

Anthouli-Anagnostopoulou, F; Desou, D; Katostaras, T; Plessa, H; Anagnostopoulou, A

dc.contributor.author	Anthouli-Anagnostopoulou, F	en
dc.contributor.author	Desou, D	en
dc.contributor.author	Katostaras, T	en
dc.contributor.author	Plessa, H	en
dc.contributor.author	Anagnostopoulou, A	en
dc.date.accessioned	2014-03-01T01:53:38Z
dc.date.available	2014-03-01T01:53:38Z
dc.date.issued	2004	en
dc.identifier.issn	10116575	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/27087
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-3242740240&partnerID=40&md5=4b6e23835c57ee405f69a207a8fd9685	en
dc.subject	Bbenign breast diseases	en
dc.subject	Ductal breast cancer	en
dc.subject	Fibroadenoma	en
dc.subject	Fibrocystic disease	en
dc.subject	Histological picture	en
dc.subject	Intraductal papilloma	en
dc.subject	Lobular breast cancer	en
dc.subject	Malignant breast diseases	en
dc.subject	Mastitis	en
dc.subject	Sclerosing adenosis	en
dc.subject.other	age	en
dc.subject.other	article	en
dc.subject.other	benign tumor	en
dc.subject.other	breast cancer	en
dc.subject.other	breast disease	en
dc.subject.other	breast duct ectasia	en
dc.subject.other	breast fat necrosis	en
dc.subject.other	breast fibroadenoma	en
dc.subject.other	breast intraductal papilloma	en
dc.subject.other	breast intratubular fibroadenoma	en
dc.subject.other	breast invasive ductal cancer	en
dc.subject.other	breast lipoma	en
dc.subject.other	breast lobular cancer	en
dc.subject.other	breast lobular ductal cancer	en
dc.subject.other	breast sclerosing adenosis	en
dc.subject.other	breast tumor	en
dc.subject.other	cancer grading	en
dc.subject.other	cancer localization	en
dc.subject.other	cell differentiation	en
dc.subject.other	disease association	en
dc.subject.other	fat necrosis	en
dc.subject.other	female	en
dc.subject.other	fibrocystic breast disease	en
dc.subject.other	histopathology	en
dc.subject.other	human	en
dc.subject.other	intraductal carcinoma	en
dc.subject.other	liposarcoma	en
dc.subject.other	lymph node metastasis	en
dc.subject.other	lymphoblastoma	en
dc.subject.other	lymphocytoma	en
dc.subject.other	multiple cancer	en
dc.subject.other	retrospective study	en
dc.title	Breast diseases: Histopathological study of six hundred forty-two cases	en
heal.type	journalArticle	en
heal.publicationDate	2004	en
heal.abstract	The purpose of the present study is the short presentation of the clinico-histopathological picture of the most frequent breast diseases and the detection of those which could coexist with other breast diseases tumorous or not, benign or malignant. 642 cases concerning different categories of breast diseases, were histologically examined during a five-year period, according to a) the affected breast (right, left, or both), b) the patient's age, c) the histologic type, and d) the presence of other breast disease, benign or malignant. Particularly, in malignant diseases, except the above parameters, were also examined a) the histological type of breast cancer in association with the grade of cell differentiation, b) the presence of multifocal breast cancer, and c) the association of breast histological type and grade of cell differentiation with the presence or absence of lymph nodes metastases. The retrospective analytical study of 642 cases showed that benign breast diseases are more frequent than the malignant ones (percentage of 59.2% and 40.8% accordingly). Benign breast lesions are usually located in the right breast (47.7%) and are often observed at the age of 41-50 years old (28.5%, p<0.005), while a smaller percentage (0.3%) is observed in old women (>81yrs). Fibrocystic disease is the most frequent benign breast lesion, comprises the 51.6% of benign diseases and has the ability to be associated with other benign breast lesions such as a) sclerosing adenosis (14.8%), b) intratubular fibroadenoma (5.6%), c) intraductal papilloma (2.5%), d) fat necrosis (2.5%), e) duct ectasia (0.5%) and lipoma (0.5%). As it concerns the malignant breast diseases, breast cancer is the most frequent disease with major histologic types the invasive ductal (80%) cancer, the lobular (14.1%) and the lobular-ductal cancer (5.9%), whereas diseases like liposarcoma (0.38%) and lymphoblastic/lymphocytic lymphoma (0.38), are rare. Median patient's age was 57.65 yrs (p=0000) with older and younger ages the 88 yrs and 31 yrs accordingly. 49.4% of the patients had cancer located in right breast, 97.7% had invasive cancer, while the 2.3% had a multifocal one. Invasive ductal breast cancer (IDC) had a 31.5% percentage of moderate cell differentiation (Grade II) and showed a high percentage of lymph nodes metastases (52%, p=0.071). Fibrocystic breast disease has a 34% association with malignant breast lesions and is more often associated with ductal (26.1%) than lobular (5.3%) breast carcinomas Other benign lesions, such as sclerosing adenosis, fibroadenomas, fat necrosis and lipoma, are hardly associated (5%) and usually appear with specific histologic types (invasive ductal and non invasive or in situ lobular) breast cancer. Conclusively, a positive association between specific histologic types of breast diseases is observed. This association concerns both benign and malignant breast lesions, sharing an important role in the development of the most frequent female malignancy, the breast cancer.	en
heal.journalName	Epitheorese Klinikes Farmakologias kai Farmakokinetikes	en
dc.identifier.volume	22	en
dc.identifier.issue	2	en
dc.identifier.spage	73	en
dc.identifier.epage	86	en