Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Fregoli symptoms

Papageorgiou, C; Lykouras, L; Ventouras, E; Uzunoglu, N; Christodoulou, GN

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Lykouras, L	en
dc.contributor.author	Ventouras, E	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Christodoulou, GN	en
dc.date.accessioned	2014-03-01T11:44:30Z
dc.date.available	2014-03-01T11:44:30Z
dc.date.issued	2002	en
dc.identifier.issn	0278-5846	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/36980
dc.subject	Delusional Misidentification Syndrome	en
dc.subject	event-related potentials	en
dc.subject	P300	en
dc.subject	working memory	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Psychiatry	en
dc.subject.other	SCHIZOPHRENIA	en
dc.subject.other	TOMOGRAPHY	en
dc.subject.other	DISORDER	en
dc.title	Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Fregoli symptoms	en
heal.type	other	en
heal.identifier.primary	10.1016/S0278-5846(01)00293-7	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0278-5846(01)00293-7	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component of event-related potentials (ERPs) is considered as an index of the,on-line updating of WM, the present study is focused on auditory P300 elicited during a WM test in DMS, compared with that in healthy controls. ERPs, elicited during a WM test, in a case suffering from coinciding Capgras and Fregoli symptoms, were recorded. Peak amplitude and latency of the averaged P300 waveforms, as well as memory performance of this case, were compared to the patterns obtained from healthy controls. In relation to normal controls, the patient exhibited significantly attenuated amplitude of P300 at the F4, P3 and Pz abductions. The patient also showed significantly prolonged latencies of P300 at all abductions used. These findings suggest that DMS may be accompanied by WM dysfunction affecting brain regions outside the prefrontal cortex, as well as within, and by diffuse failure to allocate attention resources to a stimulus, as they are reflected by P300 amplitudes and latencies respectively. Additionally, it may be suggested that techniques designed to explore cognitive operations, such as recording of ERPs, and more specifically P300, during WM tasks, could provide further insights into the relationship between neural functioning and the cognitive deficits in DMS. (C) 2002 Elsevier Science Inc. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY	en
dc.identifier.doi	10.1016/S0278-5846(01)00293-7	en
dc.identifier.isi	ISI:000177066700019	en
dc.identifier.volume	26	en
dc.identifier.issue	4	en
dc.identifier.spage	805	en
dc.identifier.epage	810	en