Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Fregoli symptoms

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dc.contributor.author Papageorgiou, C en
dc.contributor.author Lykouras, L en
dc.contributor.author Ventouras, E en
dc.contributor.author Uzunoglu, N en
dc.contributor.author Christodoulou, GN en
dc.date.accessioned 2014-03-01T11:44:30Z
dc.date.available 2014-03-01T11:44:30Z
dc.date.issued 2002 en
dc.identifier.issn 0278-5846 en
dc.identifier.uri http://hdl.handle.net/123456789/36980
dc.subject Delusional Misidentification Syndrome en
dc.subject event-related potentials en
dc.subject P300 en
dc.subject working memory en
dc.subject.classification Clinical Neurology en
dc.subject.classification Neurosciences en
dc.subject.classification Pharmacology & Pharmacy en
dc.subject.classification Psychiatry en
dc.subject.other SCHIZOPHRENIA en
dc.subject.other TOMOGRAPHY en
dc.subject.other DISORDER en
dc.title Abnormal P300 in a case of delusional misidentification with coinciding Capgras and Fregoli symptoms en
heal.type other en
heal.identifier.primary 10.1016/S0278-5846(01)00293-7 en
heal.identifier.secondary http://dx.doi.org/10.1016/S0278-5846(01)00293-7 en
heal.language English en
heal.publicationDate 2002 en
heal.abstract The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component of event-related potentials (ERPs) is considered as an index of the,on-line updating of WM, the present study is focused on auditory P300 elicited during a WM test in DMS, compared with that in healthy controls. ERPs, elicited during a WM test, in a case suffering from coinciding Capgras and Fregoli symptoms, were recorded. Peak amplitude and latency of the averaged P300 waveforms, as well as memory performance of this case, were compared to the patterns obtained from healthy controls. In relation to normal controls, the patient exhibited significantly attenuated amplitude of P300 at the F4, P3 and Pz abductions. The patient also showed significantly prolonged latencies of P300 at all abductions used. These findings suggest that DMS may be accompanied by WM dysfunction affecting brain regions outside the prefrontal cortex, as well as within, and by diffuse failure to allocate attention resources to a stimulus, as they are reflected by P300 amplitudes and latencies respectively. Additionally, it may be suggested that techniques designed to explore cognitive operations, such as recording of ERPs, and more specifically P300, during WM tasks, could provide further insights into the relationship between neural functioning and the cognitive deficits in DMS. (C) 2002 Elsevier Science Inc. All rights reserved. en
dc.identifier.doi 10.1016/S0278-5846(01)00293-7 en
dc.identifier.isi ISI:000177066700019 en
dc.identifier.volume 26 en
dc.identifier.issue 4 en
dc.identifier.spage 805 en
dc.identifier.epage 810 en

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