Copper and carcinogenesis

Theophanides, T; Anastassopoulou, J

dc.contributor.author	Theophanides, T	en
dc.contributor.author	Anastassopoulou, J	en
dc.date.accessioned	2014-03-01T11:44:30Z
dc.date.available	2014-03-01T11:44:30Z
dc.date.issued	2002	en
dc.identifier.issn	1040-8428	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/36982
dc.subject	Cancer	en
dc.subject	Copper	en
dc.subject	DNA-damage	en
dc.subject	Free radicals	en
dc.subject	Oxidative stress	en
dc.subject	Toxicity	en
dc.subject.classification	Oncology	en
dc.subject.classification	Hematology	en
dc.subject.other	ceruloplasmin	en
dc.subject.other	copper	en
dc.subject.other	copper ion	en
dc.subject.other	copper protein	en
dc.subject.other	free radical	en
dc.subject.other	hydroxyl radical	en
dc.subject.other	metal	en
dc.subject.other	reactive oxygen metabolite	en
dc.subject.other	superoxide	en
dc.subject.other	carcinogenesis	en
dc.subject.other	DNA adduct	en
dc.subject.other	DNA binding	en
dc.subject.other	DNA damage	en
dc.subject.other	human	en
dc.subject.other	nonhuman	en
dc.subject.other	oxidation reduction reaction	en
dc.subject.other	oxidative stress	en
dc.subject.other	review	en
dc.subject.other	stereochemistry	en
dc.subject.other	Animals	en
dc.subject.other	Copper	en
dc.subject.other	DNA	en
dc.subject.other	DNA Adducts	en
dc.subject.other	DNA Damage	en
dc.subject.other	Free Radicals	en
dc.subject.other	Humans	en
dc.subject.other	Metalloproteins	en
dc.subject.other	Mice	en
dc.subject.other	Neoplasms	en
dc.subject.other	Neoplasms, Experimental	en
dc.subject.other	Oxidation-Reduction	en
dc.subject.other	Oxidative Stress	en
dc.subject.other	Rats	en
dc.subject.other	Reactive Oxygen Species	en
dc.title	Copper and carcinogenesis	en
heal.type	other	en
heal.identifier.primary	10.1016/S1040-8428(02)00007-0	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S1040-8428(02)00007-0	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O-2(-) and OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases. (C) 2002 Published by Elsevier Science Ireland Ltd.	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	Critical Reviews in Oncology/Hematology	en
dc.identifier.doi	10.1016/S1040-8428(02)00007-0	en
dc.identifier.isi	ISI:000175260200005	en
dc.identifier.volume	42	en
dc.identifier.issue	1	en
dc.identifier.spage	57	en
dc.identifier.epage	64	en